Asthma Clinical Trial
Official title:
Aerosol Deposition in Asthmatic Obese Women Using Heliox: A Randomized, Crossover, Controlled Clinical Trial Study
BACKGROUND: The aim of this study was to assess pulmonary deposition and distribution of radio-aerosol in obese and normal women, using 2-D planar scintigraphy. METHODS: after inhaling an aerosol of technetium labeled diethylenetriamine penteacetic acid (99mTc - DTPA) with an activity of 1 mCi in a total dose volume with normal saline of 2,5 ml using a vibrating mesh inhaler.
BACKGROUND: Obese asthmatics are difficult to treat effectively, worse asthma control, and
do not respond as well to standard therapy as lean asthmatic. Medical aerosols an important
route of drug delivery in asthma, but narrowing in the airway cause by the obesity, can
provoke turbulence and the effectiveness of the treatment could be compromise.
AIM: To assess pulmonary deposition, distribution of radio-aerosol and analyze upper way
dimension in obese and normal weight women, using 2-D planar scintigraphyand and computed
tomography. METHODS: 20 obese women, 10 asthmatics and 10 non-asthmatics took part of the
first part of the study. Anthropometric and clinical assessments were carried out, than lung
function was performed. After randomization of the sequence of gas (sequence 1- oxygen and
heliox; sequence 2-heliox and heliox) that would be used to inhale an aerosol with
technetium labeled diethylenetriamine penteacetic acid (99mTc - DTPA) with an activity of 1
mCi in a total dose volume with normal saline of 2,5 ml using a vibrating mesh inhaler. All
patients inhaled two times with one week of washout between then to eliminate risk of
residual trace radiation and to avoid the possibility of bias.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Single Blind (Subject), Primary Purpose: Treatment
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