| Eligibility |
Inclusion Criteria:
1. Subject's written informed consent obtained prior to any study related procedure.
2. Able to understand the study procedures, the risks involved and ability to be trained
to use the devices correctly.
3. Male and female subjects aged 18 to 55 years inclusive.
4. Body mass index (BMI) within the range of 18 to 30 kg/m2 inclusive.
5. Non- or ex-smokers who smoked < 5 pack years (pack-years = the number of cigarette
packs per day, times the number of years) and stopped smoking > 1 year prior to
screening.
6. Good physical and mental status, determined on the basis of the medical history and a
general clinical examination, at screening and before randomization.
7. Lung function measurements within normal limits (Normal values (according to GINA 2014
document): FEV1/FVC > 0.70 and FEV1 > 80% predicted).
8. Male subjects: they and/or their partner must be willing to use an approved method of
contraception from the time of screening and until 30 days after the last dose of
study. Subjects must not donate sperm for 30 days after the last dose of study drug.*
9. Female subjects: post-menopausal women having at least 12 months of natural
(spontaneous) amenorrhea, or women of childbearing potential (defined as all women
physiologically capable of becoming pregnant), using an acceptable method of
contraception
10. Surgical sterilization (i.e. bilateral tubal ligation, hysterectomy for females;
vasectomy for males)
11. Hormonal contraception (implantable, injectable, patch, oral)
12. Double-barrier methods: condom and occlusive cap (diaphragm or cervical/vault caps)
13. Placement of an intrauterine device (IUD) or intrauterine system (IUS).
Exclusion Criteria:
1. Blood donation (equal or more than 450 ml) or blood loss, less than 8 weeks before
inhalation of the study medication.
2. Female subjects: pregnant or lactating women (where pregnancy is defined as the state
of a female after conception and until the termination of the gestation) confirmed by
a positive urine test at screening and randomization.
3. Positive HIV1 or HIV2 serology.
4. Positive results from the Hepatitis serology which indicates acute or chronic
Hepatitis B or Hepatitis C.
5. Unsuitable veins for repeated venipuncture.
6. History of alcohol abuse within 12 months prior to screening.
7. History of drug abuse within 12 months prior to screening (or positive urine drug test
performed at screening).
8. Subjects who have a positive urine test for cotinine.
9. Clinically relevant abnormal laboratory values suggesting an unknown disease and
requiring further clinical investigation. Note: In case of abnormal laboratory values,
the test can be performed again once before randomization.
10. Clinically relevant and uncontrolled hepatic, gastrointestinal, endocrine, metabolic,
neurologic, or psychiatric disorder that may interfere with successful completion of
this protocol.
11. History of glaucoma, symptomatic prostatism or urinary retention.
12. Subjects who have cardiovascular condition such as, but not limited to, unstable
ischemic heart disease, NYHA Class III/IV left ventricular failure, acute ischemic
heart disease in the last year prior to study screening, history of sustained cardiac
arrhythmias or sustained and non-sustained cardiac arrhythmias diagnosed in the last 6
months (sustained means lasting more than 30 seconds and or ending only with external
action, and or leads to hemodynamic collapse; non-sustained means > 3 beats < 30
seconds, and or ending spontaneously, and or asymptomatic), impulse conduction high
degree blocks, ICD implant
13. Abnormal ECG (i.e.: QRS > 120 msec, PR > 220 msec, HR < 40 bpm, HR > 110 bpm, QTcF >
450 ms for males or QTcF > 470 ms for females) at screening.
Note: In case of abnormal ECG, the test can be performed again once before
randomization.
14. Clinically significant abnormal 24h-Holter monitoring at screening (if necessary the
Holter evaluation can be done on another day before randomization).
15. Abnormal Blood Pressure (Average Diastolic Blood Pressure > 90 mmHg or average
Systolic Blood Pressure > 140 mmHg) at screening.
Note: In case of abnormal blood pressure, measure can be done again once before
randomization.
16. Participation in another clinical trial where investigation drug was received less
than 8 weeks prior to screening.
17. History of hypersensitivity to any of the excipients contained in the formulations
used in the trial.
18. Subject taking any drug treatment, including prescribed or OTC medicines as well as
vitamins, homeopathic remedies etc, taken in the 14 days before the screening with the
exception of :
1. Occasional paracetamol (maximum 2 g per day with a maximum of 10 g per 14 days
for mild non-excluding conditions);
2. Hormonal contraceptives;
3. Hormonal replacement treatment for post-menopausal women.
19. Subject taking treatment, with enzyme-inducing or enzyme-inhibiting drugs and biologic
drugs and with any drug known to have a well-defined potential for hepatotoxicity
(e.g. isoniazide, nimesulide, ketoconazole), taken since 3 months before screening
until randomization.
20. Heavy caffeine drinker (> 5 caffeinated beverages e.g., coffee, tea, cola per day).
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