ASTHMA Clinical Trial
Official title:
EXHALED AIR TEMPERATURE (TAE) AS A MARKER OF AIRWAY INFLAMMATION IN ASTHMA
The goals : to develop and computerize equipment for measuring ITAE , compare the results
with TAEP Itae study the possible relationship between different markers of inflammation:
sputum eosinophils , FeNO , the ITAE and TAEP and see the influence spirometry or a
bronchodilator in measuring the ITAE .
It has designed a line of work studying the following aspects :
1. Comparison with TAEP ITAE in a group of healthy and stable asthmatics 60 patients , 30
asthma and 30 volunteers .
Two . Study of the relationship between the number of eosinophils in sputum, FeNO , the ITAE
and TAEP , 30 patients randomly FeNO , the ITAE and TAEP be measured.
Three . ITAE measurement before and after the spirometry test , 20 patients , in stable
phase will be measured before and after the ITAE spirometry .
April . ITAE baseline measurement and after administration of 400 micrograms of salbutamol ,
20 patients diagnosed with asthma , phase stable , they measure the ITAE before and fifteen
minutes after administration of salbutamol .
May . Measurement in patients Itae a bronchial provocation test with methacholine was
performed , 20 patients were measured and baseline Itae after administration of methacholine
.
6. Measuring Itae in patients during an asthma exacerbation and stable phase , 20 patients
during an exacerbation , the ITAE be measured. Already in clinically stable measurement is
repeated.
The goals : to develop and computerize equipment for measuring ITAE , compare the results
with TAEP Itae study the possible relationship between different markers of inflammation:
sputum eosinophils , FeNO , the ITAE and TAEP and see the influence spirometry or a
bronchodilator in measuring the ITAE .
It has designed a line of work studying the following aspects :
1. Comparison with TAEP ITAE in a group of healthy and stable asthmatics 60 patients , 30
asthma and 30 volunteers .
Two . Study of the relationship between the number of eosinophils in sputum, FeNO , the ITAE
and TAEP , 30 patients randomly FeNO , the ITAE and TAEP be measured.
Three . ITAE measurement before and after the spirometry test , 20 patients , in stable
phase will be measured before and after the ITAE spirometry .
April . ITAE baseline measurement and after administration of 400 micrograms of salbutamol ,
20 patients diagnosed with asthma , phase stable , they measure the ITAE before and fifteen
minutes after administration of salbutamol .
May . Measurement in patients Itae a bronchial provocation test with methacholine was
performed , 20 patients were measured and baseline Itae after administration of methacholine
.
6. Measuring Itae in patients during an asthma exacerbation and stable phase , 20 patients
during an exacerbation , the ITAE be measured. Already in clinically stable measurement is
repeated.
;
Intervention Model: Single Group Assignment, Masking: Single Blind (Investigator), Primary Purpose: Screening
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