Asthma Clinical Trial
Official title:
Determinants Of Oral Corticosteroid Responsiveness in Wheezing Asthmatic Youth
The aim of the prospective cohort study is to: (1) document the magnitude of response to oral corticosteroids administered to children presenting to the emergency department with moderate or severe asthma and (2) quantify clinically available potential determinants of the response to corticosteroids, such as age, gender, triggers of the index exacerbation, environmental tobacco smoke (ETS), gene polymorphisms, and their interactions.
The objective of the large multicentre cohort study is to quantify the response to oral
corticosteroids in children aged 1 to 17 years presenting to the ED with a moderate or
severe asthma exacerbation.
The main outcome is hospital admission within 72 hours of the oral corticosteroid
administration.
Secondary outcomes include the change in Pediatric Respiratory Assessment Measure (PRAM),
length of active treatment and other markers of response to therapy in the ED as well as
markers of recovery over the next 10 days.
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Observational Model: Cohort, Time Perspective: Prospective
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