Asthma Clinical Trial
Official title:
Mechanisms of Response to Diesel Exhaust in Subjects With Asthma
In a controlled exposure setting, the study's goal is to determine the acute effect of diesel exhaust (DE) inhalation on airway inflammation and hyperresponsiveness (AHR) in subjects with mild to moderate stable asthma, using non-invasive measures.
The investigators will also characterize selected polymorphisms in glutathione-S-transferase
(GST) genes that have been implicated in susceptibility to air pollutants. Outcome measures
will include lung function, bronchial responsiveness to bronchodilator, exhaled nitric
oxide, induced sputum for inflammatory markers (IL6 and IL8), and exhaled breath condensate
for nitrite, 8-isoprostane, 20-HETE (20-hydroxyeicosatetraenoic acid), nitrotyrosine and pH.
In this pilot project, parallel studies are being carried out in the human exposure chambers
at two NIEHS centers, the EOHSI-CEED (Environmental and Occupational Health Sciences
Institute- Center for Environmental Exposure and Disease) and the Penn-CEET (University of
Pennsylvania-Center of Excellence in Environmental Toxicology). The joint project will
enable each center to validate research results in a second population and include new
biomarkers of pulmonary inflammation. Each center will recruit, consent, and collect data on
its own subjects. Only de-identified data will be shared between the centers.
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