Severe Asthma Research Program - University of Virginia — SARP3  

Asthma Clinical Trial

Official title: The Severe Asthma Research Program at University of Virginia - Airway Redox Biochemistry as a Determinant of Asthma Phenotype During Adolescence

Status Recruiting

Clinical Trial Summary

The overall goal of this proposal is to better understand the basis of airway remodeling in severe asthma and how remodeling changes overtime. The investigators propose to study a well characterized cohort of individuals with severe asthma using a multidisciplinary state-of-the-art-approach.

Clinical Trial Description

Through innovative metabolomics and redox biochemistry, methodologies that are a strength and unique to our collaborative efforts, the investigators identified clinically relevant phenotypes of asthma. The phenotypes are defined by biomarkers specific to underlying biochemical mechanistic abnormalities, including eosinophil-mediated oxidation, depletion of antioxidants and protective airway S-nitrosothiols, and airway acidification. Here,the investigators propose to study a new component that is informative for longitudinal assessment of severe asthma phenotypes: gender effects. The investigators reason that identification of the metabolic mechanism(s) underlying onset of severe asthma in young women during adolescence, and resolution of severe asthma in boys, will reveal fundamental pathophysiology of severe asthma. Importantly, we aim to develop clinical testing procedures to accurately assign metabolic asthma phenotypes; and to follow patients in each phenotype to uncover clinical longitudinal outcomes. At the conclusion of the project, we anticipate that we will have 1) developed clinically relevant tests to identify severe asthma phenotypes; 2) determined the longitudinal outcome of the phenotypes; and 3) identified the mechanisms underlying the preponderance of women in the severe asthma population. This application will focus on the development or clinically relevant metabolic tests to identify subphenotypes of adults and children with severe asthma and will lead to new targeted innovative treatments. ;

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

• Asthma

• NCT number: NCT01761058
• Study type: Observational
• Source: University of Virginia
• Contact: Donna L Wolf, PhD
• Phone: 434-982-4206
• Email: dlw9t@virginia.edu
• Status: Recruiting
• Phase: N/A
• Start date: December 2012
• Completion date: May 2017