Asthma Clinical Trial
Official title:
Dietary Interventions and Asthma Treatment: A Pilot Study of the Effects of Whole Sprouts on Upper Airway Allergic Inflammation
The primary objective of this study is to determine if broccoli sprouts (BS) improves nasal
inflammatory, oxidative stress (OS), and symptom responses to nasal mouse allergen challenge
(NAC) in mouse-sensitized adults perennial allergic rhinitis.
The study is a double-blind, placebo-controlled, randomized trial to compare BS to placebo
in 24 mouse-sensitized adults with asthma or perennial rhinitis and who develop rhinitis
symptoms with nasal mouse allergen challenge. Twenty-four adults (age 18-50) who meet these
eligibility criteria will be randomized to receive either: (a) BS or (b) placebo. At the
baseline NAC, FENO, FEV1, nasal epithelial gene expression, urinary OS biomarkers, serum
inflammatory and OS biomarkers, basophil activation, and symptoms will be assessed both
before and after NAC to establish pre-intervention responses to NAC. Subjects will eat a
sprouts sandwich daily for three days, and then undergo repeat NAC that includes measurement
of the above outcomes both before and after NAC.
n/a
Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment
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