Asthma Clinical Trial
Official title:
Asthma Exacerbations in Young Children With Moderate Asthma - Prospective Evaluation of Predictors
The purpose of this study is to determine whether parameters of the pulmonary function tests and the bronchial hyperresponsiveness to methacholine are predictors of asthma exacerbations.
Preliminary investigations from our own research group showed that lung function parameters
(FEV1, the FEV1/FVC ratio and a moderate to severe hyperresponsiveness to methacholine
challenge were risk factors of asthma exacerbations (OR 11.3). In the present study, these
parameters will be evaluated in prospective design.
One hundred children will be included in the study. Baseline parameters will be collected in
a healthy interval (visit 1), then the children will be followed up for 1 year. If the
patients fulfill the criteria for an exacerbation the children will present in our
department. We expect that 44% of the children have an exacerbation. All children will
present at a second visit after one year (visit 2).
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Observational Model: Case-Crossover, Time Perspective: Prospective
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