Asthma Clinical Trial
Official title:
Use of the AeroEclipse II Breath Actuated Nebulizer for the Delivery of Methacholine Chloride Bronchoprovocation Agent: A Pilot Study.
Traditional, continuous-mode nebulizers such as the English-Wright nebulizer are designed to
operate continuously with tidal breathing. As inhalation accounts for only about one-third
of the respiratory cycle, two-thirds of the continuously produced aerosol is lost to the
environment possibly posing a hazard any fellow-patients, family members, or health-care
workers in the vicinity. The English-Wright has been the only American Thoracic Society
(ATS)recommended device available on the market. Recently Roxon Medi-Tech has announced the
discontinuation of the English-Wright nebulizer. For these reasons it is necessary to review
the use of other nebulizers such as the AeroEclipse II breath-actuated nebulizer and further
validate their performance.
The investigators expect to show equivalence between the AeroEclipse II and the
English-Wright nebulizers.
This study would like to determine if the use of the Aeroeclipse II breath actuated nebulizer for the delivery of methacholine chloride bronchoprovocation agent to the lungs results in the same Provocation Concentration PC20 (provocation concentration, or dose that causes a 20% decrease in Forced Expiratory Volume in 1 sec or FEV1) as using the English-Wright nebulizer for the delivery of methacholine chloride bronchoprovocation agent to the lungs. ;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Treatment
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