Mouse Allergen and Asthma Intervention Trial

Asthma Clinical Trial

— MAAIT  

Official title:

Mouse Allergen and Asthma Intervention Trial

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01251224
• Other study ID #: 1U01AI083238
• Status: Completed
• Phase: Phase 3
• First received: November 29, 2010
• Last updated: March 15, 2017
• Start date: November 2010
• Est. completion date: September 2016

Study information

• Verified date: March 2017
• Source: Johns Hopkins University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The MAAIT is a randomized, controlled trial of a home intervention to reduce mouse allergen exposure in mouse allergic children with asthma and mouse allergen exposure. Participants will be randomized to either the Integrated Pest Management (IPM) Group or the Education Group. The IPM Group will receive professional mouse abatement, education, two HEPA filters, allergen-proof mattress and pillow encasements, and targeted cleaning. The Education Group will receive education about IPM at the beginning of the trial and then after completion of the trial, will receive the IPM intervention. Participants will be followed for 12 months.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 361
• Est. completion date: September 2016
• Est. primary completion date: September 2016
• Accepts healthy volunteers: No
• Gender: All
• Age group: 6 Years to 17 Years

Eligibility

Inclusion Criteria:

• persistent asthma

• exacerbation, previous 12 months

• evidence of mouse sensitization

• high levels of mouse allergen in home

• ages 5-17 years

Exclusion Criteria:

• intermittent asthma

• no exacerbation in previous 12 months

• not sensitized to mouse

• low or undetectable mouse allergen in home

• other lung disease aside from asthma

Related Conditions & MeSH terms

• Asthma
• Mouse Allergen Exposure
• Mouse Allergy

Intervention

Other:
• Integrated Pest Management
The IPM intervention will include professional mouse abatement, two HEPA filters, targeted cleaning, education about IPM, and allergen-proof mattress and pillow encasements. The intervention will be delivered at baseline to the IPM Group, and then repeated if recurrent or persistent mouse infestation is present.
• Education
This group will receive education about mouse IPM.

Locations

Country	Name	City	State
United States	Johns Hopkins	Baltimore	Maryland
United States	Boston Children's	Boston	Massachusetts

Sponsors (3)

Lead Sponsor	Collaborator
Johns Hopkins University	Boston Children’s Hospital, Columbia University

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	change in asthma symptoms	days of asthma symptoms	0, 3, 6, 9, 12 months