Asthma Clinical Trial
Official title:
The Effect of Montelukast on Inflammatory Responses of Nasal Epithelial Cells Cultured From Patients With Asthma, With and Without Concomitant Allergic Rhinitis
The airways of the lung are lined by specialised cells called airway epithelial cells. As well as being at the interface between the lungs and the air we breathe; airway epithelial cell (AEC) function is altered in people with respiratory diseases such as asthma. AEC secrete many mediators that contribute to asthma symptoms and these also contribute to asthmatic inflammation in the lungs. The study of such cells is difficult because of their location deep in the lungs. Nasal airway epithelial cells provide a useful and easily accessible model of model of lower airway cells. This study will examine whether the asthma medication Singulair (montelukast) can inhibit the inflammatory secretions of nasal AEC of asthmatic patents who also have allergic rhinitis compared with patients who have asthma alone. We will also examine if montelukast has differential modulating effects in these two patient groups.
Hypothesis
The inflammatory secretory profile of nasal airway epithelial cells (NEC) cultured from
asthmatics with concomitant allergic rhinitis (AR) will differ from that of NEC from patients
with asthma alone. Treatment (in vitro and in vivo) with montelukast may have differential
modulating effects in these two patient groups.
For the primary objective of this proposal we will use nasal AEC from asthmatics with or
without concomitant AR as to ascertain differences in pro-inflammatory cytokine and chemokine
production between these two groups and determine whether in vitro treatment with montelukast
has a differential modulating effect on NEC secretion. In the secondary pilot study any
modulating effects by montelukast on AEC secretion in vitro will be correlated with any in
vivo response to montelukast withdrawal. This sub study will provide pilot data indicating
whether in vivo response to montelukast can be predicted from in vitro effects on NEC.
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