The Effects of Broccoli Sprout Extract on Obstructive Lung Disease

Asthma Clinical Trial

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00994604
• Other study ID #: RB-001
• Status: Completed
• Phase: N/A
• First received: October 13, 2009
• Last updated: August 31, 2015
• Start date: October 2009
• Est. completion date: August 2015

Study information

• Verified date: August 2015
• Source: Johns Hopkins University
• Contact: n/a
• Is FDA regulated: No
• Health authority: United States: Food and Drug Administration
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is to examine whether broccoli sprout extract can effect lung function measurements in individuals with asthma and COPD.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 150
• Est. completion date: August 2015
• Est. primary completion date: August 2015
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 18 Years to 65 Years

Eligibility

Inclusion Criteria:

• asthma

• COPD

Exclusion Criteria:

• currently on chronic oral steroid medications

• current respiratory symptoms

• pregnant

• FEV1 less than 40% predicted at baseline

• extreme degrees of bronchial hyperreactivity

• recent respiratory infection (<3 weeks)

• unstable symptoms in the prior month

• a history of intubation for respiratory symptoms within the past year

• any history of cardiac disease.

Study Design

Allocation: Non-Randomized, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Basic Science

Related Conditions & MeSH terms

• Asthma
• COPD

Intervention

Drug:
• broccoli sprout extract
consumption of broccoli sprout extract for 2 weeks

Locations

Country	Name	City	State
United States	Johns Hopkins Medical Institutions	Baltimore	Maryland

Sponsors (1)

Lead Sponsor	Collaborator
Johns Hopkins University

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	The primary outcome is the change in bronchodilation and bronchoprotection after broccoli sprout extract		end of study	No
Secondary	Change in biomarkers, Change in inflammatory mediators, Change in airway distensibility, Change in parenchyma		end of study	No