Asthma Clinical Trial
Official title:
Management of Patients With Moderate to Severe Asthma Uncontrolled When Treated With Low Dose Inhaled Corticosteroids: Cost-effectiveness of Three Therapeutics Alternatives
This study is an economic evaluation of Symbicort (Budesonide/formoterol) as maintenance and
reliever therapy (SMART) versus its competitive alternatives.
The aims of this study are:
- To estimate the relative effectiveness of each one of the alternatives in the
management of patients with moderate to severe asthma through a systematic review for
the following outcomes:
- Cumulative incidence of asthma severe exacerbations symptoms
- Safety of each alternative (frequency of adverse events and complications due to
the medications)
- To estimate the direct medical costs of treating with each pharmacologic alternative:
Symbicort as SMART versus increased use of inhaled corticosteroids or Adding
long-acting inhaled beta 2 agonist plus inhaled corticosteroids.
- To create a decision analysis model (decision tree) that allows comparisons between the
alternatives on expected values and costs.
- To calculate the average and incremental cost-effectiveness ratios.
- To carry out a sensitivity analysis to test de robustness of the cost-effectiveness
results allowing for reasonable changes in expected values and costs.
n/a
Observational Model: Cohort
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