Airway Responsiveness and Inflammation in Adolescent Elite Swimmers: a 3-Year Prospective Follow-up Study

Asthma Clinical Trial

Official title:

Airway Responsiveness and Inflammation in Adolescent Elite Swimmers: a 3-Year Prospective Follow-up Study

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT00841425
• Other study ID #: H-B-2009-012
• Status: Recruiting
• Phase: N/A
• First received: February 10, 2009
• Last updated: February 23, 2009
• Start date: February 2009
• Est. completion date: June 2010

Study information

• Verified date: February 2009
• Source: Bispebjerg Hospital
• Contact: Lars Pedersen, MD PhD
• Phone: (+45) 35 31 30 69
• Email: lars.pedersen[@]dadlnet.dk
• Is FDA regulated: No
• Health authority: Denmark: The Regional Committee on Biomedical Research EthicsDenmark: Danish Dataprotection Agency
• Study type: Observational

Clinical Trial Summary

Previously the investigators have found that adolescent elite swimmers, who have been involved in competitive swimming for only a few years, have not developed respiratory symptoms, signs of airway inflammation or airway hyperresponsiveness exept for a slight increase in airway responsiveness to eucapnic voluntary hyperpnea. In the current study, the investigators will be doing a 3-year follow-up study on the swimmers studied previously.

Description:

Even though studies suggest that elite sport can cause AHR and airway inflammation, more studies are needed to elucidate how and when AHR and airway inflammation develop; and there is a lack of follow-up studies. The present study will give us a chance to do a follow-up study to register changes in AHR and airway inflammation in athletes without any significant airway changes at baseline.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 33
• Est. completion date: June 2010
• Est. primary completion date: June 2009
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 15 Years to 19 Years

Eligibility

Inclusion Criteria:

• Age 15-19 years

• Part of the Danish National Swimming Association's talent program for young swimmers at the baseline study

• Informed consent

Exclusion Criteria:

• Upper respiratory tract infection in the previous 4 weeks (visits will be postponed)

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

• Asthma

Locations

Country	Name	City	State
Denmark	Respiratory and Allergy Research Unit, Department of Respiratory Medicine L, Bispebjerg Hospital	Copenhagen

Sponsors (1)

Lead Sponsor	Collaborator
Bispebjerg Hospital

Country where clinical trial is conducted

Denmark, 

References & Publications (1)

Pedersen L, Lund TK, Barnes PJ, Kharitonov SA, Backer V. Airway responsiveness and inflammation in adolescent elite swimmers. J Allergy Clin Immunol. 2008 Aug;122(2):322-7, 327.e1. doi: 10.1016/j.jaci.2008.04.041. Epub 2008 Jun 12. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Airway responsiveness to eucapnic voluntary hyperpnea and methacholine		Three years	No
Secondary	Airway inflammation		Three years	No