Prevalence of Exercise-Induced Asthma in Select Cohorts of College Athletes

Asthma Clinical Trial

Official title:

Prevalence of Exercise-Induced Asthma in Select Cohorts of College Athletes

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00806000
• Other study ID #: 2008H0094
• Status: Completed
• Phase: N/A
• First received: December 9, 2008
• Last updated: October 9, 2012
• Start date: December 2008
• Est. completion date: December 2010

Study information

• Verified date: October 2012
• Source: Ohio State University
• Contact: n/a
• Is FDA regulated: No
• Health authority: United States: Institutional Review Board
• Study type: Observational

Clinical Trial Summary

This study is investigating how commonly exercise-induced asthma happens in athletes and the best way to diagnose exercise-induced asthma. Exercise-induced asthma describes narrowing of the airways in the lungs that occurs in certain people when they exercise. This can cause shortness of breath, cough, and fatigue during exercise and can impair athletic performance. Exercise-induced asthma can be difficult to diagnose. This is a research study, because the investigators are examining the best way to document a diagnosis of exercise-induced asthma. The investigators are also interested in examining why exercise-induced asthma may occur.

Description:

prospective, cohort study of the prevalence of asthma in select athletic teams at a large, collegiate athletic program as documented by self-report versus lung function testing. Athletes from men's and women's ice hockey, soccer, and lacrosse will be studied. Each athlete will indicate via self-report on questionnaires whether they have asthma, and then subsequently will be tested utilizing specialized lung function testing. These teams were chosen, because it will allow for gender-matching across teams and they had subjectively reported asthma prevalence rates based on prior pilot data.

Inclusion Criteria:

1. Varsity athlete on athletic team of interest here at The Ohio State University

2. 18 years of age or older

3. No short-acting bronchodilator use for 6 hours prior to testing

4. No long-acting bronchodilator use for 36 hours prior to testing

5. No inhaled corticosteroids or leukotriene modifiers for 72 hours prior to testing

6. Non-smoker for 6 months or longer

7. Less than 10 pack year (number of packs per day (x) years of smoking=pack years) smoking history, as smoking causes chronic changes in the profile of inflammatory cells of lungs and also makes airways more likely to spasm. This is true even for non-smokers.

Exclusion criteria:

1. pregnancy

2. recent upper respiratory tract infection (within 2 weeks of study enrollment)

3. Objective evidence of severe lung impairment on pulmonary testing performed at the beginning of the study.

4. Participation in another interventional research trial

5. Unable to provide consent

6. Asthma exacerbation within the last 4 weeks

Recruitment information / eligibility

• Status: Completed
• Enrollment: 150
• Est. completion date: December 2010
• Est. primary completion date: December 2010
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Varsity athlete on athletic team of interest here at The Ohio State University

• 18 years of age or older

• No short-acting bronchodilator use for 6 hours prior to testing

• No long-acting bronchodilator use for 36 hours prior to testing

• No inhaled corticosteroids or leukotriene modifiers for 72 hours prior to testing

• Non-smoker for 6 months or longer

• Less than 10 pack year (number of packs per day (x) years of smoking=pack years) smoking history, as smoking causes chronic changes in the profile of inflammatory cells of lungs and also makes airways more likely to spasm. This is true even for non-smokers

Exclusion Criteria:

• pregnancy

• recent upper respiratory tract infection (within 2 weeks of study enrollment)

• Objective evidence of severe lung impairment on pulmonary testing performed at the beginning of the study.

• Participation in another interventional research trial

• Unable to provide consent

• Asthma exacerbation within the last 4 weeks

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

• Asthma
• Asthma, Exercise-Induced

Locations

Country	Name	City	State
United States	The Ohio State University	Columbus	Ohio

Sponsors (1)

Lead Sponsor	Collaborator
Ohio State University

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Secondary	To identify characteristics of athletes that may be associated with increased relative risk for asthma To identify characteristics of athletes that may be associated with increased relative risk for asthma. To identify characteristics of athletes tha		end of study	No