Study Evaluating the Safety and Effects of MN-221 in Subjects With Moderate to Severe Asthma

Asthma Clinical Trial

Official title:

A Randomized, Single-blind, Parallel Group, Placebo-controlled, Dose Rate Escalation Study Evaluating the Safety and Effects of MN-221 in Subjects Diagnosed With Moderate to Severe Asthma

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00679263
• Other study ID #: MN-221-CL-005
• Status: Completed
• Phase: Phase 2
• First received: May 14, 2008
• Last updated: December 14, 2011
• Start date: February 2008
• Est. completion date: July 2008

Study information

• Verified date: November 2011
• Source: MediciNova
• Contact: n/a
• Is FDA regulated: No
• Health authority: United States: Food and Drug Administration
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is to evaluate the safety and tolerability of MN-221 at two different dosing rates administered through a continuous infusion in subjects diagnosed with moderate to severe asthma.

Description:

This is a multi-center, randomized, single-blind*, parallel group, placebo-controlled, study with two dosing regimens in subjects diagnosed with moderate to severe asthma using MN-221 or placebo. Subjects will be randomized to receive MN-221 or placebo in a 3:1 ratio, MN-221:placebo. Subjects randomized to receive MN-221 will be dosed with active study drug at both dosing visits, and subjects randomized to the placebo arm will receive placebo at both dosing visits. Approximately 25 subjects diagnosed with moderate to severe asthma who have not received inhaled corticosteroid therapy within one month of Screen Visit 1 will be enrolled and will participate throughout the study.

Initial dose:

• 16 μg/min for 15 minutes followed by 8 μg/min for 105 minutes (2-hour infusion with a total dose of 1,080 μg MN-221 or Placebo)

Subsequent dose:

• 30 μg/min for 15 minutes followed by 15 μg/min for 45 minutes (1-hr infusion with a total dose of 1,125 μg MN-221 or Placebo)

There will be approximately a two to four week period between each dose regimen, during which time a safety review will be performed before proceeding to the next dose level. Subjects will be screened for eligibility and continued eligibility will be determined for each subject prior to administering each dose. After the initiation of the intravenous infusion of MN-221 or placebo, serial spirometry will be measured for approximately 24 hours.

For each dose evaluation period, subjects will be domiciled in the clinical research unit (CRU) for 2 nights, beginning on Day -1, one day before dosing. Determination of continued study eligibility will be made on Day -1 for each dose level. Day 1 will include study drug infusion and approximately a 24-hour observation period into Day 2 to allow safety monitoring, serial spirometry, and serum PK measurements. Subjects will be discharged from the CRU on Day 2. They will return to the CRU approximately 2-4 weeks later to participate in the subsequent dose group.

*This is a "modified" single-blind study in which the subject and Investigator are both blinded regarding the treatment arm.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 17
• Est. completion date: July 2008
• Est. primary completion date: July 2008
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 18 Years to 50 Years

Eligibility

Inclusion Criteria:

1. Male or female subjects;

2. Must sign an informed consent;

3. Diagnosis of asthma as defined by the American Thoracic Society for at least 3 months;

4. Must not be receiving inhaled corticosteroids for control within 1 month of study;

5. Must have an increase in FEV1 of at least 12% and 200 cc over the pre-albuterol FEV1 within 30 minutes after inhalation of up to 4 puffs of albuterol via a metered dose inhaler;

6. Non-smoker for at least 6 months and in good health;

7. Female subjects must have a negative pregnancy test;

8. Male and female subjects of child-bearing potential (not surgically sterile or post menopausal) must be abstinent or agree to use contraceptive regimens throughout the study;

9. Subjects receiving allergy desensitization therapy can participate as long as they have been on a stable maintenance dose for = 6 months;

10. Subject must be willing and able not to use inhaled bronchodilators for 6 hours before and until 24 hours after each study drug administration at all study visits; and

11. Subject must demonstrate mental and physical ability and willingness to follow all study-specific instructions pertaining to the scheduling of study visits and assessments.

Exclusion Criteria:

1. Have significant cardiopulmonary, renal, hepatic, endocrine, metabolic, neurological or other systemic disease;

2. Received emergency treatment for asthma within 1 month, or hospitalized for asthma within 3 months;

3. Had an upper or lower respiratory tract infection within 3 weeks, or sinus infection within 7 days;

4. Have participated in a clinical study with an investigational drug, other than an MN-221 study, within 30 days;

5. Have history or evidence of drug or alcohol abuse within 2 years of study entry;

6. Female subjects who are pregnant or lactating;

7. Taking any of the following excluded asthma/allergy medications within the time periods indicated prior to the first study visit:

• Oral, inhaled, or parenteral corticosteroids for 1 month prior to the first study visit.

• Anti-IgE medication for 3 months prior to the first study visit.

• Theophylline, long-acting bronchodilators, and anti-cholinergics for 2 weeks prior to the first study visit.

8. Taking leukotriene modifiers and not on a stable daily dosage for 4 weeks prior to the first study visit.

9. Taking antihistamines, nasal corticosteroids, or decongestants and not on a stable dose for 3 days prior to any dosing day.

10. Have a known allergy to MN-221 or any of the other components of the study drug (i.e. lactose);

11. Have a history of frequent episodes of orthostatic hypotension or any predisposition for orthostatic hypotension;

12. Have used any prescription or over-the-counter medication, vitamin or herbal supplement (except as listed in Inclusion Criterion 7 and Exclusion Criterion 7-10) within 7 days of study entry, or the expected need to use any unapproved prescription or over-the-counter medication or supplement seven days prior to the first study visit until completion of the study;

13. Taking any drugs or substances known to be strong inhibitors of cytochrome P450 enzymes within 10 days of study entry, or the expected need to use such drugs ten days prior to the first study visit until after completion of the study;

14. Taking any drugs or substances known to be strong inducers of cytochrome P450 enzymes within 28 days of study entry, or the expected need to use such drugs prior to completion of the study;

15. Adhering to any special diet that is not well balanced within 28 days of study entry;

16. Have donated (standard donation amount or more) blood or blood products (with the exception of plasma noted below) within 56 days of study entry;

17. Have donated plasma within 7 days of study entry;

18. Have any laboratory value outside the laboratory reference range that is considered to be clinically significant;

19. Have any abnormal vital signs (B/P, respiratory rate, heart rate) considered to be clinically significant;

20. Have positive results for drug and/or alcohol screen;

21. Have any clinically significant ECG abnormality, including a corrected QT interval (QTc) > 450 msec; and/or

22. Have any other medical condition or reason that, in the Investigator's opinion, makes the subject unsuitable to participate in this clinical trial.

Study Design

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Subject), Primary Purpose: Treatment

Related Conditions & MeSH terms

• Asthma

Intervention

Drug:
• MN-221
Initial dose: 16 µg/min for 15 minutes followed by 8 µg/min for 105 minutes (2-hour infusion with a total dose of 1,080 µg)
• MN-221
Subsequent dose: 30 µg/min for 15 minutes followed by 15 µg/min for 45 minutes (1-hr infusion with a total dose of 1,125 µg).
• Placebo
Placebo intravenous infusion with dosing volume equivalent to active treatment.

Locations

Country	Name	City	State
United States	Greenville Pharmaceutical Research	Greenville	South Carolina
United States	PRA International	Lenexa	Kansas
United States	Northeast Medical Research Associates	North Dartmouth	Massachusetts
United States	Clinical Research of the Ozarks	Rolla	Missouri

Sponsors (1)

Lead Sponsor	Collaborator
MediciNova

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Number of Patients Reported to Have Adverse Events		Day 1 to Day 2	Yes
Secondary	FEV1 Percent Predicted Changes From Base Line	The primary efficacy variable will be the change from baseline in FEV1, expressed as percent of predicted at hour 1 after the start of the infusion. Analysis of all other variables at all other time points will be considered secondary.	Day 1 to Day 2	No