Asthma Clinical Trial
Official title:
Identification of Biomarkers in Exhaled Breath Condensates From Asthmatic Patients
This study will look for a relationship between asthma and factors released from the lungs in
exhaled breath. If a relationship can be established, the identified factors may be used as
biomarkers to predict episodes of increased asthma symptoms so that medications can be given
to prevent the onset of an asthma attack.
Healthy volunteers and people who have had asthma for at least 1 year may be eligible for
this study. Candidates must be between 18 and 75 years of age.
Participants undergo blood tests and breathing tests. For the latter, participants breathe
into a machine before and after inhaling an asthma medication called albuterol. The machine
measures the volume of air the subject can breathe out. Participants also provide a sample of
exhaled breath by breathing normally for up to 30 minutes while wearing a mask devised for
the procedure. Pulse rate, oxygen saturation and wheezing are monitored during the breath
collection.
Asthma is a major public health problem that is associated with significant morbidity and mortality. Patients at increased risk for asthma decompensations include those with severe asthma that is refractory to therapy, as well as patients with poorly controlled disease due to inadequate treatment. The aim of this exploratory specimen procurement protocol is to develop a non-invasive method for the detection of asthma-specific biomarkers in exhaled breath condensates (EBC) utilizing a novel collection device that was engineered at the Johns Hopkins University Applied Physics Laboratory. Biomarkers in EBC will be identified by mass spectroscopy. We propose that the identification of biomarkers in EBC that correlate with airway inflammation and disease activity may be used to guide therapy and prevent exacerbations in asthmatic patients. ;
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