Clinical Trial Details
— Status: Completed
Administrative data
| NCT number |
NCT00541255 |
| Other study ID # |
1408 |
| Secondary ID |
R01HL0829251R01H |
| Status |
Completed |
| Phase |
|
| First received |
|
| Last updated |
|
| Start date |
September 2007 |
| Est. completion date |
February 18, 2015 |
Study information
| Verified date |
February 2023 |
| Source |
Isle of Wight NHS Trust |
| Contact |
n/a |
| Is FDA regulated |
No |
| Health authority |
|
| Study type |
Observational
|
Clinical Trial Summary
Asthma is a common disease that is often diagnosed in childhood. In some teenagers, asthma
symptoms disappear and treatment can be stopped; however, for some of these people, asthma
symptoms return in adulthood. This study will examine data collected over the lifetime of
18-year olds to identify factors that may increase a person's chance of having recurrent
asthma as an adult.
Description:
Asthma is a serious, long-term illness that affects around 15% of children in the United
States. During adolescence, up to 50% of teenagers stop experiencing symptoms and are able to
discontinue treatment. However, asthma symptoms often reoccur in adulthood for many of these
people. It is not known exactly what causes this recurrence, but potential risk factors may
include obesity, elevated serum leptin levels, early onset of puberty, exposure to
pollutants, parental smoking habits, and lack of breastfeeding. Additionally, it is not known
why childhood asthma is initially more prevalent in boys, but during adolescence it becomes
more prevalent in girls. Beginning in 1989, a group of children born on the Isle of Wight in
the United Kingdom has been followed by study researchers to provide long-term information on
asthma. These children have been periodically evaluated over the years and are now 18 years
old. The purpose of this study is to analyze participants' data collected over a span of 18
years to identify factors that may increase a person's risk of experiencing persistent or
recurrent asthma in adulthood.
At previous study visits that occurred when participants were 1, 2, 4, and 10 years old,
information on the following was collected: asthma and other allergic diseases, family
history of asthma, and early life risk factors, including breastfeeding and tobacco smoke
exposure. A blood sample was collected at participants' 10-year study visit. For this current
study, all 18-year-old participants will return for a study visit. Participants will complete
questionnaires on asthma and allergy symptoms and environmental exposures, including tobacco
smoke and pollution. Blood collection, an allergy skin prick test, lung function testing, and
a bronchial challenge test to assess airway function will occur. Select participants will
also have a sputum sample collected.
