Bronchoprotection of Salbutamol in Asthma and Chronic Obstructive Pulmonary Disease

Asthma Clinical Trial

Official title: Bronchoprotection of Salbutamol in Asthma and COPD

Status Completed

Clinical Trial Summary

This study will investigate potential differences in how two puffs of salbutamol protects airway smooth muscle from contracting in people with asthma and chronic obstructive pulmonary disease (COPD).

Clinical Trial Description

In asthma, the administration (inhalation) of a selective β2 receptor agonist (e.g. salbutamol), prior to methacholine challenge has been shown to shift the dose response curve to the right and "bronchoprotect" the airway against airway smooth muscle contraction. The extent of β2 receptor agonist bronchoprotection in COPD is unknown.

Airway hyperresponsiveness (AHR) to direct acting agents such as histamine and methacholine is a feature of both asthma and COPD. In asthma, the abnormality leading to AHR is believed to be due to changes in airway smooth muscle (e.g. hypertrophy, hyperplasia, contractile apparatus) whereas in COPD the AHR is likely due to structural or geometric changes.

The investigators hypothesize that the bronchoprotection afforded by salbutamol against methacholine challenge will be greater in asthma than in COPD due to differences in underlying airway abnormalities. ;

Related Conditions & MeSH terms

• Asthma
• COPD

• NCT number: NCT00440245
• Study type: Interventional
• Source: University of Saskatchewan
• Status: Completed
• Phase: Phase 4
• Start date: February 2007
• Completion date: July 2010