Asthma Clinical Trial
Official title:
Pilot Study of Statin Treatment in Patients With Stable Moderate to Severe Asthma
Asthma is a chronic respiratory condition characterized by bronchial hyper-responsiveness secondary to abnormal inflammation of the lung. Steroids remain the most effective treatment for this condition. The lipid lowering agents statins have been found to have anti-inflammatory properties. This study is to test the hypothesize that statins will decrease bronchial hyperresponsiveness and inflammation, leading to improved symptoms in patients with asthma.
Asthma affects 7 - 12 % of the population in North America and results in substantial
morbidity and health care costs. Management of asthma is focused towards reducing airway
inflammation through a combination of avoidance of inciting and triggering pro-inflammatory
agents as well as anti-inflammatory medication. Corticosteroids and anti-leukotrienes are
efficacious, but are neither universally effective nor free of side effects. Statins, which
are currently widely prescribed and used safely to improve serum lipids and cholesterol,
have anti-inflammatory properties which may be clinically useful in asthma either in
addition to or perhaps instead of corticosteroids.
The objective of this research proposal is to conduct a randomized placebo controlled trial
of 4 weeks statin therapy in patients in moderate to severe but stable asthma. We
hypothesize that statins may directly reduce airway inflammation and/or contribute to the
anti-inflammatory effects of corticosteroid treatment in these patients. We will measure the
effects of statins by measuring airway sensitivity to methacholine, pulmonary function,
sputum eosinophils, and quality of life in subjects with asthma after 4 weeks of treatment.
Statins may become an alternative treatment option or act as steroid sparing agents in
patients with asthma.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment
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