Asthma Clinical Trial
To evaluate asthma morbidity in low-income, African-American children and adults with asthma.
BACKGROUND:
Asthma is a serious chronic condition affecting over 14 million Americans, but the
prevalence rates are higher in certain populations (e.g. 10 percent in inner-cities and 30
percent among the homeless vs. 5 percent in a general population of whites). African
Americans and Hispanics from the Northeast are twice as likely to die from asthma as whites.
African Americans are four times as likely to be hospitalized for asthma and are five times
more likely than whites to seek care for asthma at an emergency department. Reasons for
these higher rates are not certain, and most likely result from an interaction of risk
factors such as environmental exposures, genetic predisposition, access to appropriate
medical care, socioeconomic status, and cultural health practices. The National Heart, Lung,
and Blood Institute supports a variety of activities to address the pressing public health
problems posed by asthma. However, progress in reducing disparities has been disappointingly
slow. Separate, independent research projects have generated important clues for
understanding the nature and scope of the problem. A more coordinated, interdisciplinary and
comprehensive approach to research is needed to take advantage of these clues, move the
science further and faster, and increase our capacity to improve health outcomes among
minority and economically disadvantaged populations. Cooperative centers of research that
foster partnerships among minority medical centers, research intensive institutions, and the
communities in which asthma patients live will promote such advancement.
The Request for Applications for the Centers for Reducing Asthma Disparities was released in
October, 2001. The objective of the program is to promote partnerships (called Centers)
between a minority serving institution (MSI) that may not have a strong research program and
a research intensive institution (RII) that has a track record of NIH-supported research and
patient care. The purpose of the partnership is to conduct collaborative research on asthma
disparities (i.e. greater prevalence of asthma, higher rates of morbidity due to asthma, and
lesser access or use of quality medical care among minorities and poor).
DESIGN NARRATIVE:
The center has four research projects designed to collaboratively investigate factors
associated with the disproportionate burden of asthma experienced by inner-city,
African-American children and adults. This includes studies that will evaluate both the
underlying genetic factors that may contribute to the observed excess risk in
African-American communities, as well as studies of provider-patient communication designed
to assess intervention strategies for remediating this risk. In addition, an essential goal
of the Howard/Hopkins Center for Reducing Asthma Disparities will be to create a culturally
sensitive training environment that is truly reciprocal, and designed to both enrich and
enhance the research potential and asthma management capabilities of both participating
institutions.
Research project 1 will create and validate a culturally sensitive and simple to administer
Asthma Communication Instrument for use in describing asthma symptoms. Research project 2
will develop a tripartite communication mechanism between the patient, the patient care
provider, and an asthma counselor. Research project 3 deals with the genetics of cockroach
allergy. Research project 4 will develop a complementary mouse model to address the role of
the genetics of cockroach sensitization as it pertains to asthma disparities.
The study completion date listed in this record was obtained from the "End Date" entered in
the Protocol Registration and Results System (PRS) record.
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N/A
Status | Clinical Trial | Phase | |
---|---|---|---|
Terminated |
NCT04410523 -
Study of Efficacy and Safety of CSJ117 in Patients With Severe Uncontrolled Asthma
|
Phase 2 | |
Completed |
NCT04624425 -
Additional Effects of Segmental Breathing In Asthma
|
N/A | |
Active, not recruiting |
NCT03927820 -
A Pharmacist-Led Intervention to Increase Inhaler Access and Reduce Hospital Readmissions (PILLAR)
|
N/A | |
Completed |
NCT04617015 -
Defining and Treating Depression-related Asthma
|
Early Phase 1 | |
Recruiting |
NCT03694158 -
Investigating Dupilumab's Effect in Asthma by Genotype
|
Phase 4 | |
Terminated |
NCT04946318 -
Study of Safety of CSJ117 in Participants With Moderate to Severe Uncontrolled Asthma
|
Phase 2 | |
Completed |
NCT04450108 -
Vivatmo Pro™ for Fractional Exhaled Nitric Oxide (FeNO) Monitoring in U.S. Asthmatic Patients
|
N/A | |
Completed |
NCT03086460 -
A Dose Ranging Study With CHF 1531 in Subjects With Asthma (FLASH)
|
Phase 2 | |
Completed |
NCT01160224 -
Oral GW766944 (Oral CCR3 Antagonist)
|
Phase 2 | |
Completed |
NCT03186209 -
Efficacy and Safety Study of Benralizumab in Patients With Uncontrolled Asthma on Medium to High Dose Inhaled Corticosteroid Plus LABA (MIRACLE)
|
Phase 3 | |
Completed |
NCT02502734 -
Effect of Inhaled Fluticasone Furoate on Short-term Growth in Paediatric Subjects With Asthma
|
Phase 3 | |
Completed |
NCT01715844 -
L-Citrulline Supplementation Pilot Study for Overweight Late Onset Asthmatics
|
Phase 1 | |
Terminated |
NCT04993443 -
First-In-Human Study to Evaluate the Safety, Tolerability, Immunogenicity, and Pharmacokinetics of LQ036
|
Phase 1 | |
Completed |
NCT02787863 -
Clinical and Immunological Efficiency of Bacterial Vaccines at Adult Patients With Bronchopulmonary Pathology
|
Phase 4 | |
Recruiting |
NCT06033833 -
Long-term Safety and Efficacy Evaluation of Subcutaneous Amlitelimab in Adult Participants With Moderate-to-severe Asthma Who Completed Treatment Period of Previous Amlitelimab Asthma Clinical Study
|
Phase 2 | |
Completed |
NCT03257995 -
Pharmacodynamics, Safety, Tolerability, and Pharmacokinetics of Two Orally Inhaled Indacaterol Salts in Adult Subjects With Asthma.
|
Phase 2 | |
Completed |
NCT02212483 -
Clinical Effectiveness and Economical Impact of Medical Indoor Environment Counselors Visiting Homes of Asthma Patients
|
N/A | |
Recruiting |
NCT04872309 -
MUlti-nuclear MR Imaging Investigation of Respiratory Disease-associated CHanges in Lung Physiology
|
||
Withdrawn |
NCT01468805 -
Childhood Asthma Reduction Study
|
N/A | |
Recruiting |
NCT05145894 -
Differentiation of Asthma/COPD Exacerbation and Stable State Using Automated Lung Sound Analysis With LungPass Device
|