Asthma Clinical Trial
Official title:
Asthma, a Disease Due to a Lack of Bacterial Infections in Childhood.
The degree of TH1-skewing by mycobacteria is controlles by NRAMP1 gene polymorphisms and related to the degree of inhibition of TH2-mediated disease.
A randomised single blinded intervention study in high-risk newborns vaccinated at the age
of 6 weeks with BCG or placebo.
Inclusion: high-risk was defined as either a mother or a father and a sibling with present
or past atopic disease.
Exclusion: maternal infection in the last week of pregnancy, the use of immunomodulatory
drugs or antibiotics during pregnancy (mother), the use of antibiotics directly post-partum
(newborn)
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind, Primary Purpose: Prevention
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