Asthma Clinical Trial
Official title:
Health Effects of Diesel Exhaust in Asthmatic Patients: A Real-world Study in a London Street
Acute exposure to diesel exhaust under normal city conditions leads to a worsening of
symptoms of asthma, with reduction in lung function in asthmatic nonsmoking adults, dependent
on the exposure dose and on the background severity of asthma.
The worsening asthma is accompanied by increased oxidative stress and inflammation in the
lungs.
The investigators will recruit 60 nonsmoking asthmatics of mild and of moderate severity. They will be exposed to Oxford St. or to Hyde Park for 2 hours each, at a walking pace. Real time exposure to PM2.5, carbon monoxide and nitrogen dioxide will be made each time. Health outcome measurements will be made before and after exposure to each street. Statistical analyses will be made to examine the effect of diesel exposure on changes in health outcome measures. ;
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