Health Effects of Early-Life Exposure to Urban Pollutants in Minority Children

Asthma Clinical Trial

Official title:

Health Effects of Early-Life Exposure to Urban Pollutants in Minority Children

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00043498
• Other study ID #: 8977-CP-001
• Status: Completed
• Phase: N/A
• First received: August 9, 2002
• Last updated: October 14, 2014
• Start date: August 1997
• Est. completion date: May 2013

Study information

• Verified date: October 2014
• Source: National Institute of Environmental Health Sciences (NIEHS)
• Contact: n/a
• Is FDA regulated: No
• Health authority: United States: Federal Government
• Study type: Observational

Clinical Trial Summary

A molecular epidemiologic study of African American and Hispanic mothers and newborns to investigate the role of common urban pollutants on procarcinogenic and developmental damage.

Description:

The major objective of the proposed research is to study the impact of early-life exposures to common urban pollutants on neurobehavioral development and asthma in a sample of children living in three low-income, minority communities of New York City (Central Harlem, Washington Heights and the South Bronx). Using a molecular epidemiologic approach with monitoring, biomarkers, and clinical assessments at serial time points, we will extend our study of African-American and Latina urban mothers and children in order to follow the cohort through child age 11 years to assess the longer-term impact of exposures on child health and developmental outcomes.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 727
• Est. completion date: May 2013
• Est. primary completion date: May 2013
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Female
• Age group: 18 Years to 35 Years

Eligibility

Enrollment eligibility was restricted to nonsmoking pregnant women 18-35 years of age who self-identified as either African American or Dominican and who had resided in northern Manhattan or the South Bronx in New York City for at least 1 year before pregnancy. Women were excluded if they used illicit drugs, had diabetes, hypertension, or known HIV, or had their first prenatal visit after the 20th week of pregnancy.

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

• Asthma
• Development

Locations

Country	Name	City	State
United States	Columbia University, 722 W 168th St, 12th Floor	New York	New York

Sponsors (1)

Lead Sponsor	Collaborator
National Institute of Environmental Health Sciences (NIEHS)

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Neurobehavioral development		1 to 12 years	No
Primary	Asthma		2-12 years	No