Asthma Clinical Trial
Official title:
Genetic Epidemiology of Asthma in Costa Rica
To identify genetic factors that influence the development of asthma in Hispanics.
BACKGROUND:
Asthma is a major public health problem in the United States, with particularly high
prevalence rates among some Hispanic groups. Genetic linkage studies of this disease are of
potentially great utility for the identification of those at risk, the search for new
pharmaceutical treatments, and designing interventions to prevent development of asthma.
Study power is greatly enhanced if a relatively isolated, homogeneous population with a
significant prevalence of asthma can be identified. Such a population does not exist among
Hispanics in the United States but is available in the Central Valley of Costa Rica.
DESIGN NARRATIVE:
The study concentrates on a genetically isolated Hispanic population with high asthma
prevalence living in the Central Valley of Costa Rica. A genome screen will be conducted on
large pedigrees multiplex for asthma and linkage analysis performed for seven intermediate
phenotypes related to asthma including airway responsiveness; FEV1; bronchodilator
responsiveness; skin test reactivity to common aeroallergens; serum total and
allergen-specific IgE; and peripheral blood eosinophil count. A genome screen will also be
conducted in the parent-child trios, and ancestral haplotypes will be reconstructed to
identify regions influencing asthma-associated phenotypes. Within candidate regions
demonstrating both linkage in extended pedigrees to asthma and/or asthma-related phenotypes
and significant linkage disequilibrium within the unrelated asthmatic subjects, fine mapping
will be performed by testing for genetic association to single nucleotide polymorphisms
within positional candidate genes.
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Observational Model: Family-Based, Time Perspective: Cross-Sectional
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