Asthma Clinical Trial
To prospectively examine the association between a specific chronic life stressor (i.e., intimate violence exposure) and adult asthma in women.
BACKGROUND:
Etiologies of the rising prevalence and morbidity of asthma are not well understood.
Knowledge gaps are particularly significant with respect to adult-onset asthma. The role of
stress in the expression of asthma is largely unexplored in large-scale, prospective,
epidemiologic studies and such investigation has been identified as a priority by a recent
NHLBI expert panel.
DESIGN NARRATIVE:
The study prospectively examines the association between a specific chronic life stressor
(i.e., intimate violence exposure) and adult asthma in women participating in the Nurses'
Health Study II cohort. Emerging epidemiologic data suggest that exposure to intimate
violence is a pervasive chronic life stressor associated with adverse impact on womens'
psychological and physical health. Traumatic stress such as that related to intimate
violence exposure has been associated with neuroendocrine changes known to cause alterations
in neuroendocrine and immune functions important to the pathophysiology of inflammatory
diseases including asthma. The investigators are testing the hypothesis that women exposed
to high-level chronic stress (violence) will be at greater risk for asthma development than
women with low-level stress (violence) exposure. The influence of chronic stress on
neuroendocrine and immune function as reflected in morning cortisol expression, for the
former, and cytokine profiles and IgE production (T-helper cell polarization), for the
latter, will also be examined in a nested case control fashion among these women.
The study completion date listed in this record was obtained from the "End Date" entered in
the Protocol Registration and Results System (PRS) record.
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N/A
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