Asthma Clinical Trial
To assess the separate and interactive effects of asthma severity, subspecialty practice variation, asthma-related psychosocial variables, and other factors on asthma outcomes, including asthma-specific quality of life and activity limitations, health care utilization for asthma, and direct and indirect costs of asthma.
BACKGROUND:
Asthma is both common and costly. Neither the risk factors of poor outcome nor the
predictors of better outcome are well understood. Illness severity is clearly an important
predictive factor in asthma, but may explain less variability in outcome than other
determinants, such as patient-perceived asthma control, other asthma-related psychosocial
measures, and the kind and extent of subspecialty care for asthma. By quantifying predictors
of asthma-specific quality of life, functional status, services utilization, and the direct
and indirect illness costs of asthma, this study addressed a major research gap in secondary
and tertiary prevention efforts.
DESIGN NARRATIVE:
A random sample of pulmonary and allergy subspecialists initially enrolled 600 persons with
asthma identified in patient visit logs. This established panel completed 45 minute baseline
and follow-up computer-assisted telephone interviews (CATI); 539 (90%) were successfully
re-interviewed after 18 months of follow-up. A supplemental sampling frame of persons with
asthma identified from family practitioners was completed as was a group with rhinitis but
without asthma. Interviews assessed disease severity and other covariables using validated
survey instruments. Pulmonary function and medical records were used to validate severity in
a sub-sample of subjects. The study extended longitudinal follow-up study of this initial
cohort. Its analysis tested predictive models for the asthma outcomes of interest.
The study completion date listed in this record was obtained from the "End Date" entered in
the Protocol Registration and Results System (PRS) record.
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N/A
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