Asthma Clinical Trial
To provide information necessary for the development of standards for peak expiratory flow (PEF) test performance in populations studies.
BACKGROUND:
While PEF has routinely been applied in the diagnosis and management of asthma, scientists
were finding new applications for PEF as both a clinical and epidemiologic tool for
following individuals with pulmonary diseases, studying the natural history of chronic
obstructive pulmonary disease, and evaluating the impact of environmental exposures on lung
function. Yet the standardization of the PEF measurement lagged behind its application.
The little attention paid to the performance characteristics of the PEF maneuver contrasted
sharply with the efforts to standardize measurement procedures for FEV1 and FVC. The
American Thoracic Society devoted a great deal of attention to studying these measures and
published guidelines for the standardization of their measurement. These guidelines included
detailed protocols for calibrating equipment, administering the tests, determining
reproducibility, and interpreting results.
The research provided data on the optimal number of trials per test session, the difference
between a PEF performed during a full forced expiratory effort and that resulting from a
short blast, the impact of test supervision on test performance, and the reproducibility of
the PEF measurement.
DESIGN NARRATIVE:
A baseline survey of ventilatory function was performed using spirometry. PEF was measured
daily with a mini-Wright Peak Flow Meter over a period of several weeks in a study of 201
normals (staff, faculty and graduate students at the University of Massachusetts Lowell).
Serial PEF data were collected on a group of mild asthmatics identified in a local
occupational medicine clinic. Finally, performance characteristics were examined in serial
PEF data from two existing occupational cohort studies.
The study completion date listed in this record was obtained from the "End Date" entered in
the Protocol Registration and Results System (PRS) record.
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N/A
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