Asthma Clinical Trial
To investigate the genetics of asthma by reexamining a carefully characterized population of patients with asthma, and by studying their families.
Status | Completed |
Enrollment | 0 |
Est. completion date | May 2008 |
Est. primary completion date | May 2008 |
Accepts healthy volunteers | No |
Gender | Male |
Age group | N/A to 100 Years |
Eligibility | No eligibility criteria |
N/A
Country | Name | City | State |
---|---|---|---|
n/a |
Lead Sponsor | Collaborator |
---|---|
National Heart, Lung, and Blood Institute (NHLBI) |
Bleecker ER, Amelung PJ, Levitt RC, Postma DS, Meyers DA. Evidence for linkage of total serum IgE and bronchial hyperresponsiveness to chromosome 5q: a major regulatory locus important in asthma. Clin Exp Allergy. 1995 Nov;25 Suppl 2:84-8; discussion 95-6. — View Citation
Bleecker ER, Postma DS, Meyers DA. Evidence for multiple genetic susceptibility loci for asthma. Am J Respir Crit Care Med. 1997 Oct;156(4 Pt 2):S113-6. Review. — View Citation
Bleecker ER, Postma DS, Meyers DA. Genetic susceptibility to asthma in a changing environment. Ciba Found Symp. 1997;206:90-9; discussion 99-105, 106-10. Review. — View Citation
DiSilvestre D, Kleeberger SR, Johns J, Levitt RC. Structure and DNA sequence of the mouse MnSOD gene. Mamm Genome. 1995 Apr;6(4):281-4. — View Citation
He P, Ma Y, Zhao G, Dai H, Li H, Chang L, Zhang Z. FaRE1: a transcriptionally active Ty1-copia retrotransposon in strawberry. J Plant Res. 2010 Sep;123(5):707-14. doi: 10.1007/s10265-009-0290-0. Epub 2009 Dec 18. — View Citation
Howard TD, Bleecker ER, Stine OC. Fluorescent allele-specific PCR (FAS-PCR) improves the reliability of single nucleotide polymorphism screening. Biotechniques. 1999 Mar;26(3):380-1. — View Citation
Howard TD, Meyers DA, Bleecker ER. Mapping susceptibility genes for allergic diseases. Chest. 2003 Mar;123(3 Suppl):363S-8S. Review. — View Citation
Howard TD, Meyers DA, Bleecker ER. Mapping susceptibility genes for asthma and allergy. J Allergy Clin Immunol. 2000 Feb;105(2 Pt 2):S477-81. Review. — View Citation
Howard TD, Postma DS, Jongepier H, Moore WC, Koppelman GH, Zheng SL, Xu J, Bleecker ER, Meyers DA. Association of a disintegrin and metalloprotease 33 (ADAM33) gene with asthma in ethnically diverse populations. J Allergy Clin Immunol. 2003 Oct;112(4):717-22. — View Citation
Jongepier H, Boezen HM, Dijkstra A, Howard TD, Vonk JM, Koppelman GH, Zheng SL, Meyers DA, Bleecker ER, Postma DS. Polymorphisms of the ADAM33 gene are associated with accelerated lung function decline in asthma. Clin Exp Allergy. 2004 May;34(5):757-60. — View Citation
Koppelman GH, Jansen DF, Schouten JP, van der Heide S, Bleecker ER, Meyers DA, Postma DS. Sibling effect on atopy in children of patients with asthma. Clin Exp Allergy. 2003 Feb;33(2):170-5. — View Citation
Koppelman GH, Reijmerink NE, Colin Stine O, Howard TD, Whittaker PA, Meyers DA, Postma DS, Bleecker ER. Association of a promoter polymorphism of the CD14 gene and atopy. Am J Respir Crit Care Med. 2001 Mar;163(4):965-9. — View Citation
Koppelman GH, Stine OC, Xu J, Howard TD, Zheng SL, Kauffman HF, Bleecker ER, Meyers DA, Postma DS. Genome-wide search for atopy susceptibility genes in Dutch families with asthma. J Allergy Clin Immunol. 2002 Mar;109(3):498-506. — View Citation
Levitt RC, Ewart SL. Genetic susceptibility to atracurium-induced bronchoconstriction. Am J Respir Crit Care Med. 1995 May;151(5):1537-42. — View Citation
Levitt RC, Holroyd KJ. Fine-structure mapping of genes providing susceptibility to asthma on chromosome 5q31-q33. Clin Exp Allergy. 1995 Nov;25 Suppl 2:119-23. — View Citation
Levitt RC, Kiser MB, Dragwa C, Jedlicka AE, Xu J, Meyers DA, Hudson JR. Fluorescence-based resource for semiautomated genomic analyses using microsatellite markers. Genomics. 1994 Nov 15;24(2):361-5. — View Citation
Meyers DA, Bleecker ER. Approaches to mapping genes for allergy and asthma. Am J Respir Crit Care Med. 1995 Jul;152(1):411-3. Review. — View Citation
Meyers DA, Postma DS, Stine OC, Koppelman GH, Ampleford EJ, Jongepier H, Howard TD, Bleecker ER. Genome screen for asthma and bronchial hyperresponsiveness: interactions with passive smoke exposure. J Allergy Clin Immunol. 2005 Jun;115(6):1169-75. — View Citation
Meyers DA, Xu J, Postma DS, Levitt RC, Bleecker ER. Two locus segregation and linkage analysis for total serum IgE levels. Clin Exp Allergy. 1995 Nov;25 Suppl 2:113-5. — View Citation
Monitto CL, Levitt RC, DiSilvestre D, Holroyd KJ. Localization of the A3 adenosine receptor gene (ADORA3) to human chromosome 1p. Genomics. 1995 Apr 10;26(3):637-8. — View Citation
Oostendorp J, Postma DS, Volders H, Jongepier H, Kauffman HF, Boezen HM, Meyers DA, Bleecker ER, Nelemans SA, Zaagsma J, Meurs H. Differential desensitization of homozygous haplotypes of the beta2-adrenergic receptor in lymphocytes. Am J Respir Crit Care Med. 2005 Aug 1;172(3):322-8. Epub 2005 May 5. — View Citation
Panhuysen CI, Bleecker ER, Koeter GH, Meyers DA, Postma DS. Characterization of obstructive airway disease in family members of probands with asthma. An algorithm for the diagnosis of asthma. Am J Respir Crit Care Med. 1998 Jun;157(6 Pt 1):1734-42. — View Citation
Postma DS, Bleecker ER, Amelung PJ, Holroyd KJ, Xu J, Panhuysen CI, Meyers DA, Levitt RC. Genetic susceptibility to asthma--bronchial hyperresponsiveness coinherited with a major gene for atopy. N Engl J Med. 1995 Oct 5;333(14):894-900. — View Citation
Postma DS, Meyers DA, Jongepier H, Howard TD, Koppelman GH, Bleecker ER. Genomewide screen for pulmonary function in 200 families ascertained for asthma. Am J Respir Crit Care Med. 2005 Aug 15;172(4):446-52. Epub 2005 May 18. — View Citation
Schwengel DA, Jedlicka AE, Nanthakumar EJ, Weber JL, Levitt RC. Comparison of fluorescence-based semi-automated genotyping of multiple microsatellite loci with autoradiographic techniques. Genomics. 1994 Jul 1;22(1):46-54. — View Citation
Stine OC, Xu J, Meyers DA, Bleecker ER. Approaches to fine mapping in asthma. Clin Exp Allergy. 1998 Apr;28 Suppl 1:98-100; discussion 108-10. — View Citation
Teeter JG, Bleecker ER. Mechanisms of asthma. Curr Opin Pulm Med. 1996 Jan;2(1):23-8. Review. — View Citation
Wiesch DG, Meyers DA. Strategies for analyzing genotype-phenotype relationships in asthma. J Allergy Clin Immunol. 2000 Feb;105(2 Pt 2):S482-6. Review. — View Citation
Xu J, Bleecker ER, Jongepier H, Howard TD, Koppelman GH, Postma DS, Meyers DA. Major recessive gene(s) with considerable residual polygenic effect regulating adult height: confirmation of genomewide scan results for chromosomes 6, 9, and 12. Am J Hum Genet. 2002 Sep;71(3):646-50. Epub 2002 Jul 15. — View Citation
Xu J, Postma DS, Howard TD, Koppelman GH, Zheng SL, Stine OC, Bleecker ER, Meyers DA. Major genes regulating total serum immunoglobulin E levels in families with asthma. Am J Hum Genet. 2000 Nov;67(5):1163-73. Epub 2000 Oct 6. — View Citation
* Note: There are 30 references in all — Click here to view all references
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