Asthma Chronic, Cough Clinical Trial
Official title:
ToAST: Investigating the Effect of Bronchial Thermoplasty on Cough in Patients With Severe Asthma
ToAST study is a pilot study aiming to establish the safety profile of using inhaled capsaicin challenge in patients with severe asthma. The investigators will also explore the differences in cough symptoms and threshold in patients with and without bronchial thermoplasty.
ToAST is designed as a two-visit observational study. During visit 1, written consent and
measurements of baseline asthma characteristics were completed; history and examination,
questionnaires (Asthma Control Questionnaires and Leicester Cough Questionnaire, and basic
lung physiological assessment were performed.
At the end of visit 1, a cough monitor was attached to the subject to monitor cough frequency
for the next 24 hours and this was returned at visit 2.
Visit 2 followed within two weeks after visit 1, during which a full dose capsaicin cough
challenge was performed. Emergency contact details were given towards end of visit 2 should
any adverse events occur.
Telephone call within 48 hours, Day 3 and Day 7: The purpose of these phone calls was to
ensure that the patient had not developed any adverse effects to the capsaicin challenge.
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