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Asthenia clinical trials

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NCT ID: NCT06440265 Completed - Clinical trials for Intensive Care Unit Acquired Weakness

Validity and Reliability of Korean Version of AM-PAC Inpatient Short Form (Low Function) in Critically Ill Patients

AM-PAC
Start date: March 31, 2023
Phase:
Study type: Observational

The Activity Measure for Post Acute Care (AM-PAC) inpatient short form (low function) evaluates the level of assistance a patient requires another person to provide for distinct functional mobility and daily activities. The objective of the study was to translate and cross-culturally adapt the AM-PAC (low function) into Korean version and assess its reliability and validity . Independent raters assessed 38 patients from ICU using the Korean version of AM-PAC, respectively. Intra-class correlation coefficients (ICCs) and Bland-Altman's plots were used to evaluate reliability, and Cronbach's alpha for internal consistency. Validity was evaluated using Spearman's correlation analysis with other physical function assessment tools (functional status score for the ICU(FSS-ICU), Medical Research Council-sum score(MRC-SS), hand grip strength) and other unrelated factors (body mass index, glucose level).

NCT ID: NCT06420999 Not yet recruiting - Clinical trials for Diaphragm Dysfunction

Incidence and Impact of ICU-acquired Diaphragm Weakness

PRODIGY
Start date: June 1, 2024
Phase:
Study type: Observational

ICU survivors are at an increased risk of hospital and ICU readmission. Among the complications of ICU stay, diaphragmatic dysfunction is common, with a prevalence of 60 to 80%, and is associated with increased mortality and prolonged hospital stays. Furthermore, several studies have reported that the observation of impaired respiratory muscle function upon ICU discharge is associated with a poor long-term prognosis. However, the incidence and prognostic impact of persistent diaphragmatic dysfunction at ICU discharge have never been evaluated. The measurement of dyspnea, a composite evaluation of respiratory muscle function, has not been assessed for predicting prognosis upon ICU discharge. The hypothesis of the project is that the presence of ICU-acquired diaphragmatic dysfunction at ICU discharge is associated with a poorer prognosis within 90 days.

NCT ID: NCT06419517 Recruiting - Clinical trials for Pelvic Floor Muscle Weakness

Pelvic Muscle Training and Electrostimulation to Treat Weak Pelvic Floor

Start date: May 17, 2024
Phase: N/A
Study type: Interventional

This research will determine 1) whether the very weak pelvic floor can be improved with surface electromyography (s-EMG)-triggered electrostimulation added to pelvic floor muscle training and 2) whether sEMG-triggered electrostimulation added to pelvic floor muscle training can reduce leakage in Stress Urinary Incontinence (SUI)

NCT ID: NCT06410950 Recruiting - Copd Clinical Trials

Mechanical Muscle Proprieties in Patient With COPD

Start date: May 13, 2024
Phase:
Study type: Observational

This study aims to determine if patients with Chronic Obstructive Pulmonary Disease (COPD) exhibit altered muscle properties (specifically changes in tone and stiffness) in both their respiratory muscles and skeletal muscles when compared to healthy individuals. The study will utilize the Myotonometer, a non-invasive device, to assess these properties.

NCT ID: NCT06409611 Not yet recruiting - Clinical trials for Intensive Care Unit Acquired Weakness

MUSCLE EFFECTS OF NEUROMUSCULAR ELECTROSTIMULATION IN MECHANICALLY VENTILATED PATIENTS IN AN ICU

Start date: May 1, 2024
Phase: N/A
Study type: Interventional

To prevent the development of ICUAW, both early mobilization and neuromuscular electrical stimulation (NMES) have been shown to prevent muscle atrophy in critically ill patients by preserving muscle mass. Furthermore, it is of great value that muscle assessment using kinesiological ultrasound becomes routine to monitor this patient's profile with regard to strength, muscle quality and muscle mass. Our objective is to evaluate the muscular changes promoted by NMES in patients under mechanical ventilation. This is a randomized clinical trial study, which will perform NMES sessions for at least 10 days in mechanically ventilated patients. They will also undergo ultrasound assessments of the quadriceps. Patients will be divided into a control group and an NMES group. In addition, general information recorded in the medical record will be collected, such as basic characteristics, laboratory tests and general assessments.

NCT ID: NCT06407076 Not yet recruiting - Healthcare Clinical Trials

Strengths and Weaknesses of Physiotherapy in the Daily Work of an Intensive Care Unit

Start date: May 9, 2024
Phase:
Study type: Observational

Background. A stay in the Intensive Care Unit can cause long-term problems and physiological changes at the neuromuscular and respiratory levels in critically ill patients. Early physiotherapy in these patients is safe and feasible to avoid or reduce the adverse musculoskeletal and respiratory effects of the stay in this hospital unit. Objective. To identify the strengths and barriers of Physiotherapy in an Intensive Care Unit, according to the vision of different Health Science professionals. Method. Qualitative observational study using individual interviews and focus groups. 18 people (6 doctors, 6 nurses and 6 physiotherapists) will be included in the study. The 18 health professionals will participate in personal interviews and focus groups (3 focus groups with 6 participants each). Participants will be recruited from the Intensive Care Unit of the Hospital Universitario Central de Asturias. Data will be analysed using the thematic analysis approach according to Braun and Clarke's method. We will use face-to-face interviews and focus groups to collect data and analyse them through thematic analysis. Purposive sampling will be used to recruit our participants. We will continue to recruit participants, if necessary, until saturation of data from the thematic analysis is reached. Expected outcomes. To assess the knowledge, perceptions and expectations of the healthcare staff in the Intensive Care Unit regarding Physiotherapy in the management of patients admitted to this Unit. To identify the strengths of Physiotherapy in the management of these patients.

NCT ID: NCT06391606 Completed - Clinical trials for Hypercholesterolemia

CoQ10 in Statin-associated Asthenia

Start date: October 1, 2018
Phase: N/A
Study type: Interventional

This was a double-blind, randomized, placebo-controlled clinical study aiming to assess the effects of supplementation with CoQ10 phytosome on physical performance in older adults with self-reported statin-associated asthenia.

NCT ID: NCT06331039 Completed - Clinical trials for Urinary Incontinence

The Effects of Pelvic Floor Muscle Training Combined With Otago Exercises in Elderly People With Incontinence

Start date: April 5, 2023
Phase: N/A
Study type: Interventional

Pelvic floor muscle weakness is one of the most important causes of incontinence. There are many studies supporting that pelvic floor muscle training prevents incontinence and reduces symptom severity, and with A level of evidence, it is among the first in the conservative treatment of incontinence. Functional status and balance problems are common in elderly people with incontinence, and it is known that functional type incontinence is common. Elderly people with incontinence most often fall while trying to get to the toilet. Balance exercises are recommended for falls and balance problems. The aim of this study is to examine whether pelvic floor muscle training (PFMT) combined with Otago exercises is effective on symptoms, balance and functional status in elderly people with UI living in nursing homes, compared to PFMT alone.

NCT ID: NCT06238609 Recruiting - Muscle Weakness Clinical Trials

Neuromodulation for Prevention of Intensive Care Unit Acquired Weakness and Post Intensive Care Syndrome

Start date: August 28, 2023
Phase: Phase 1
Study type: Interventional

Post-intensive care syndrome (PICS) encompasses persistent physical, cognitive, and psychiatric symptoms following ICU discharge, commonly triggered by serious conditions such as respiratory failure, sepsis, and mechanical ventilation. PICS prevalence is reported to be as high as 84% up to 12 months in patients with at least 2 days spent in the ICU or with mechanical ventilatory support. As a consequence, many patients do not return to they former level of function for weeks, months and even years. Muscular affection manifested by muscle weakness is particularly seen and is provoked by a combination of damage to the nerves or directly the muscles fibers. This affection is referred to as CU-Acquired Weakness (ICUAW). One third of the time, lower extremities are affected, often due to prolonged immobilization or sedation. Evidence suggests that early mobilization reduces the incidence of ICUAW at discharge and improves the number of patients able of stand. However achieving this early intervention is not always feasible due to time or personnel constraints. The purpose of the study is to examine the effectiveness of lower extremity neuromodulation for prevention of muscle deconditioning in patients admitted to the ICU.

NCT ID: NCT06210763 Recruiting - Clinical trials for Intensive Care Unit Acquired Weakness

IMT Outcomes in Sufferers of Severe Walking Disabilities and Intensive Care Unit Acquired Weakness

Start date: August 2, 2023
Phase: N/A
Study type: Interventional

Intensive care unit-acquired weakness (ICU-acquired weakness) may be caused by a variety of different causes. Several studies have shown that ICU-acquired weakness occurs in up to 30% of critically ill patients. It affects daily activities, walking, and functional performance