Aspirin Exacerbated Respiratory Disease Clinical Trial
The purpose of this study is to determine whether a low salicylate diet will improve the quality of life of patients with Aspirin Exacerbated Respiratory Disease (AERD).
Aspirin-exacerbated respiratory disease (AERD) is clinically diagnosed in patients who
suffer from allergy to aspirin, asthma, nasal polyps, and chronic sinusitis. Patients with
AERD are often resistant to medical management of nasal polyps, and require multiple
endoscopic sinus surgeries to manage recurrences of nasal polyps. Control of AERD can be
obtained through aspirin desensitization, which consists of taking aspirin every day.
However, there are substantial risks and adverse side effects to taking moderate amounts of
aspirin daily. Furthermore, patients experience progressively worsening nasal and
respiratory disease even with complete avoidance of aspirin and other NSAIDs.
The active and major component in aspirin/NSAIDs is salicylate, which is also found
naturally in some foods. Diet modification is a cost-effective intervention that has the
potential to provide long-term remission of AERD. Our study will evaluate whether a low
salicylate diet, which is a more cost effective and benign intervention with minimal risks,
will improve nasal, sinus or respiratory symptoms, such as congestion, sinusitis, smell, or
asthma.
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Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Treatment
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Suspended |
NCT04261582 -
Genetics and Genomics of Aspirin Exacerbated Respiratory Disease (AERD)
|
||
| Completed |
NCT01778465 -
Effect of Dietary Salicylate in Aspirin Exacerbated Respiratory Disease
|
N/A | |
| Completed |
NCT04375293 -
Characterisation of the Nasal Microbiome in Patients With N-ERD
|
N/A |