Aspiration Clinical Trial
— AMYLASPIOfficial title:
Comparison of Two Strategies of Oropharyngeal and Tracheal Suctioning in Mechanically Ventilated Patients: a Pilot Trial
Verified date | July 2017 |
Source | University Hospital, Bordeaux |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
The purpose of this study is to evaluate the impact of an optimized suctioning procedure on the risk of endotracheal microaspiration, measured by tracheal to oropharyngeal ratio of amylase enzymatic activity.
Status | Completed |
Enrollment | 24 |
Est. completion date | March 4, 2016 |
Est. primary completion date | March 4, 2016 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: - Intubated with a subglottic secretion drainage device - ventilated more than 48 hours - patients yielding a significant tracheal suctioning volume (on a semi-qualitative evaluation: = ++ on a scale consisting of 0,+,++,+++) Exclusion Criteria: - paralysed patients - patients with Ramsay 1, 2 - patients breathing spontaneously - patients less than 18 years old - patients in a moribund state - contra-indication for suctioning procedure (risk of haemorrhage, bronchospasm, Acute Respiratory Distress Syndrome with P/F < 100, malformation or tracheal fistula) - bronchiectasis, cystic fibrosis, chronic obstructive pulmonary disease - patients necessitating a closed-suctioning device (prevention of respiratory multiresistant bacteria transmission, Acute Respiratory Distress Syndrome with P/F ratio < 100) - pregnant women |
Country | Name | City | State |
---|---|---|---|
France | Hospital Pellegrin | Bordeaux | Gironde |
Lead Sponsor | Collaborator |
---|---|
University Hospital, Bordeaux | Teleflex |
France,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | tracheal to oropharyngeal ratio of amylase enzymatic activity | As a surrogate for microaspiration, the tracheal to oropharyngeal ratio of amylase enzymatic activity will be assessed after oral care. A mean of measures realized one day after optimized oral care will be compared to a mean of measure realized the other day after standard oral care as a cross over protocol. | Day 1 and Day 2 | |
Secondary | volume of the tracheal, subglottic, and oral suctions | qualitative evaluation of volume of the tracheal, oral and when applicable subglottic suctions | three time a day, during 2 days | |
Secondary | length of each mouth care | Length in minutes of each mouth care, including tracheal, oral and when applicable subglottic, suctions | three time a day, during 2 days | |
Secondary | cost of the optimized oral suctioning compared with routine care | Mean cost of needed material and timed spented by nurses for each mouth care | At the end of the period of study (48hours) for each patient |
Status | Clinical Trial | Phase | |
---|---|---|---|
Active, not recruiting |
NCT04083677 -
Routine Point of Care Ultrasound (POCUS) Assessment of Antral Gastric Contents in Traumatic Surgical Patients for Prevention of Aspiration Pneumonitis
|
||
Terminated |
NCT05101668 -
Safety and Efficacy of Intracranial Thrombus Aspiration Catheter in the Treatment of Acute Large-vessel Occlusive Stroke
|
N/A | |
Completed |
NCT02588495 -
Accuracy of Gastric Ultrasound to Diagnose a "Full Stomach". A Bayesian Framework
|
N/A | |
Completed |
NCT02576756 -
Retrospective Study in Patients Who Have Had a Difficult Intubation.
|
N/A | |
Completed |
NCT01777672 -
Effect of Afferent Oropharyngeal Pharmacological and Electrical Stimulation on Swallow Response and on Activation of Human Cortex in Stroke Patients With Oropharyngeal Dysphagia
|
Phase 2 | |
Completed |
NCT05033041 -
Gastric Volumes by US in Term Parturients Undergoing CS With and Without Metoclopramide
|
Phase 4 | |
Recruiting |
NCT05079620 -
Early Antibiotics After Aspiration in ICU Patients
|
Phase 4 | |
Completed |
NCT01011803 -
Correlation of Phonation With Deglutition and Aspiration Risk in the ICU Patients - an Exploratory Study
|
N/A | |
Recruiting |
NCT06137976 -
Surgeon Perception of Gastric Decompression at Time of Gynecologic Laparoscopy
|
N/A | |
Completed |
NCT04645043 -
Ultrasound Guided Esophageal Pressure
|
N/A | |
Completed |
NCT03573609 -
Evaluation of the Effectiveness and Safety of Supratube Device
|
N/A | |
Completed |
NCT03555604 -
Evaluation of the Effect of Body Mass Index on Gastric Volume With Ultrasound in Term Pregnant Women
|
||
Enrolling by invitation |
NCT04411290 -
Malignancy Predictors, Bethesda and TI-RADS Scores Correlated With Final Histopathology in Thyroid Diseases
|
||
Completed |
NCT05734937 -
Ultrasound Evaluation of Gastric Volume in Pediatric Patients Undergoing Adenotonsillectomy Surgery
|
N/A | |
Recruiting |
NCT05330351 -
Gastric Ultrasound in Pediatric Trauma Patients
|
||
Terminated |
NCT02437513 -
NewBreez for Airway Protection in Head and Neck Cancer Patients With Chronic Aspiration
|
N/A | |
Completed |
NCT04786691 -
How do You Take Your Coffee Before Anesthesia
|
N/A | |
Completed |
NCT05434442 -
Caregivers Tracheal Aspiration Training
|
N/A | |
Completed |
NCT03305757 -
Seroma Reduction After Mastectomy
|
Phase 4 | |
Active, not recruiting |
NCT04202887 -
The Effect of Low-Dose vs High-Dose Epidural Fentanyl on Gastric Emptying - A Prospective Double-Blinded Randomized Controlled Trial
|
N/A |