Metoclopramide vs Placebo for Prevention of Pneumonia in Acute Stroke

Status Completed

Clinical Trial Summary

Pneumonia is a major cause of mortality and morbidity in patients with acute stroke fed via nasogastric tubes and may be because of vomiting and gastro-esophageal regurgitation. The aim of the study was to assess whether regular treatment with metoclopramide, a D2-receptor antagonist with antiemetic and gastric prokinetic actions, could reduce the rate of pneumonia.

Clinical Trial Description

Patients admitted with no signs of pneumonia within 7 days of stroke onset and 48 hours of insertion of a nasogastric tube will be recruited into a single-blind randomized placebo-controlled study who will admit in Neurology Department, PIMS. Participants will receive metoclopramide 10 mg or placebo 3 times daily via the nasogastric tube for 4 days. Clinical signs of pneumonia will be recorded on alternate days. Pneumonia will be diagnosed if the patient has relevant clinical signs, high inflammatory markers, and new infiltrates on the chest radiograph. A sample size of 106 patients is calculated, 53 patients in each group. Non-probability consecutive sampling will be used for recruitment of participants. Study duration will be six months. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04873297
Study type	Interventional
Source	Shaheed Zulfiqar Ali Bhutto Medical University
Contact
Status	Completed
Phase	Phase 4
Start date	May 2, 2021
Completion date	October 2, 2021

View Details

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