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Artificial Intelligence clinical trials

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NCT ID: NCT06187350 Recruiting - Neoplasms Clinical Trials

The Use of AI to Safely Reduce the Workload in Breast Cancer Screening With Mammography in Region Östergötland

AIM-RÖ
Start date: August 1, 2023
Phase:
Study type: Observational [Patient Registry]

The overall aim of the project is to investigate how artificial intelligence (AI) can be used to streamline and at the same time increase diagnostic safety in breast cancer screening with mammography. AI has been shown in a number of studies to have great potential for both increasing diagnostic certainty (e.g. reduced occurrence of interval cancers) and at the same time reducing the workload for doctors. However, much research remains to clinically validate these new tools and to increase the understanding of how they affect the work of doctors. The specific goal of the project is to investigate whether the implementation of AI in breast cancer screening in Östergötland, Sweden, can increase the sensitivity (the mammography examination's ability to find breast cancer) and the specificity (that is, the right case is selected for further investigation: a minimum of healthy women are recalled but so many breast cancer cases that are possible are selected for further investigation) and at the same time make screening more efficient through reduced workload. AI will be implemented in the clinical routine and performance metrics such as cancer detection rate etc will be closely monitored. The study do not assign specific interventions to the study participants.

NCT ID: NCT06164002 Recruiting - Clinical trials for Artificial Intelligence

A I in the Prediction of Clinical Performance, Marginal Fit and Fracture Resistance of Vertical Versus Horizontal Margin Designs Fabricated With 2 Ceramic Materials

Start date: September 1, 2023
Phase: N/A
Study type: Interventional

The present study will be performed to evaluate application of artificial intelligence in the prediction of clinical performance, marginal fit and fracture resistance of vertical "feather-edge" versus horizontal "shoulder" margin designs fabricated with two ceramic materials (zirconia and hybrid ceramic)

NCT ID: NCT06163781 Recruiting - Clinical trials for Artificial Intelligence

Appropriate Use of Blood Cultures in the Emergency Department Through Machine Learning

ABC
Start date: February 19, 2024
Phase: N/A
Study type: Interventional

The goal of this clinical trial is to study whether the use of our blood culture prediction tool is non-inferior to current practice and if it can improve certain outcomes in all adult patients presenting to the emergency department with a clinical indication for a blood culture analysis (according to the treating physician). The primary endpoint is 30-day mortality. Key secondary outcomes are: - hospital admission rates - in-hospital mortality - hospital length-of-stay. In the intervention group, the physician will follow the advice of our blood culture prediction tool. In the comparison group all patients will undergo a blood culture analysis.

NCT ID: NCT06140849 Recruiting - Clinical trials for Artificial Intelligence

Evaluation of Artificial Intelligence Models for Diagnosis of Anterior Open Bite Malocclusion

Start date: November 2023
Phase:
Study type: Observational

Building artificial intelligence models for diagnosis of anterior open bite malocclusion

NCT ID: NCT06073405 Recruiting - Clinical trials for Artificial Intelligence

Colonic Polyp Size Measurement With Artificial Intelligence

Start date: January 1, 2023
Phase:
Study type: Observational

Primary objective of the study is to evaluate if the novel virtual polyp sizing tool accuracy in determining the size class of polyps among diminutive (0-5 mm), small (6-9 mm) and large (10 mm and above).

NCT ID: NCT06063720 Recruiting - Clinical trials for Artificial Intelligence

Effective Withdrawal Time and Adenoma Detection Rate

Start date: November 1, 2023
Phase:
Study type: Observational

The goal of this observational study is to assess the correlation between the artificial intelligence (AI) derived effective withdrawal time (EWT) during colonoscopy and endoscopists' baseline adenoma detection rate (ADR). The association between the AI derived EWT with ADR during the prospective colonoscopy series would also be determined. The colonoscopy video of participants will be monitored by the AI and the result of EWT will be blinded to the endoscopists

NCT ID: NCT06059378 Recruiting - Clinical trials for Artificial Intelligence

Real-life Implementation of an AI-based Optical Diagnosis

AI-OD
Start date: September 1, 2023
Phase: N/A
Study type: Interventional

This is a prospective study that is the first to implement resect and discard and diagnose and leave strategies in real-time practice using stringent documentation and adjudication by 2 expert endoscopists as the gold standard. Therefore, this study mainly aims to evaluate the agreement between (CADx) assisted optical diagnosis and adjudication by two expert endoscopists in establishing surveillance intervals concordant with the European Society for Gastrointestinal Endoscopy (ESGE) and US Multisociety task force (USMSTF) guidelines.

NCT ID: NCT06051682 Recruiting - Clinical trials for Artificial Intelligence

Optimization of the Diagnosis of Bone Fractures in Patients Treated in the Emergency Department by Using Artificial Intelligence for Reading Radiological Images in Comparison With Traditional Reading by the Emergency Doctor.

FracturIA
Start date: September 11, 2023
Phase: N/A
Study type: Interventional

As part of the management of a patient with suspected bone fractures, emergency physicians are required to make treatment decisions before obtaining the imaging reading report from the radiologist, who is generally not available only a few hours after the patient's admission, or even the following day. This situation of the emergency doctor, alone interpreting the radiological image, in a context of limited time due to the large flow of patients to be treated, leads to a significant risk of interpretation error. Unrecognized fractures represent one of the main causes of diagnostic errors in emergency departments. This comparative study consists of two cohorts of patients referred to the emergency department for suspected bone fracture. The first will be of interest to patients whose radiological images will be interpreted by the reading of the emergency doctor systematically doubled by the reading of the artificial intelligence. The other will interest a group of patients cared for by the simple reading of the emergency doctor. All of the images from both groups of patients will be re-read by the establishment's group of radiologists no later than 24 hours following the patient's treatment. A centralized review will be provided by two expert radiologists. Also, patients in both groups will be systematically recalled in the event of detection of an unknown fracture for hospitalization.

NCT ID: NCT06031818 Recruiting - Clinical trials for Hepatocellular Carcinoma

Usability and Clinical Effectiveness of an Interpretable Deep Learning Framework for Post-Hepatectomy Liver Failure Prediction

Start date: December 10, 2023
Phase:
Study type: Observational

The goal of this in-silico clinical trial is to learn about the usability and clinical effectiveness of an interpretable deep learning framework (VAE-MLP) using counterfactual explanations and layerwise relevance propagation for prediction of post-hepatectomy liver failure (PHLF) in patients with hepatocellular carcinoma (HCC). The main questions it aims to answer are: - To investigate the usability of the VAE-MLP framework for explanation of the deep learning model. - To investigate the clinical effectiveness of VAE-MLP framework for prediction of post-hepatectomy liver failure in patients with hepatocellular carcinoma. In the usability trial the clinicians and radiologists will be shown the counterfactual explanations and layerwise relevance propagation (LRP) plots to evaluate the usability of the framework. In the clinical trial the clinicians and radiologists will make the prediction under two different conditions: with model explanation and without model explanation with a washout period of at least 14 days to evaluate the clinical effectiveness of the explanation framework.

NCT ID: NCT05985057 Recruiting - Clinical trials for Artificial Intelligence

A Novel Approach to Antimicrobial Resistance: Machine Learning Predictions for Carbapenem-Resistant Klebsiella in ICUs

ICU
Start date: December 1, 2023
Phase:
Study type: Observational

The aim of this study to predict carbapenem resistant Klebsiella spp. earlier in our patients monitored in our Intensive Care Unit in the future, using artificial intelligence. Patients with bloodstream infection and pneumonia caused by Klebsiella spp. will be comparatively examined in two groups, as sensitive and resistant. Resistance will be attempted to be predicted with deep machine learning.