Spectrum of Bacterial Infections in Rheumatology — SIBERIE  

Articular Disease Clinical Trial

Official title: Spectrum of Bacterial Infections in Rheumatology and the Role of Urinary Tract Infection

Status Completed

Clinical Trial Summary

Retrospective study of patients with a proved non-tuberculous osteoarticular infection (OAI) diagnosed in a rheumatology department during the years 2010-2020. The objectives are :

• To describe sites, type of micro-organism, clinical data, origin of infection, therapeutic modalities et outcome

• To compare OAI of urinary origin with those with another origin

Clinical Trial Description

This retrospective study will be conducted on medical files. Patients will be mainly selected on :

• A proved osteoarticular infection (OAI) diagnosed in the department of rheumatology of the René Dubos hospital from 1° January 2010 to 31 December 2020.

• Adult patients 18 year's old or older

• Infection proved by positive culture in the osteoarticular site and/or blood (with typical clinical and imaging features)

The followed OAI are not included :

• Infection on prosthetic joint, materiel ; post-operative OAI ; osteomyelitis

• Brucellosis ; Lyme disease

Patients are selected from the codification of the hospitalization ; medical files are reviewed by the investigators.

OAI of urinary origin is defined either by the same micro-organism in urine and osteo-articular sample (or blood) or a bacteria in the osteo-articular sample in conjunction with : urologic pathology, recurrent urinary tract infection, urologic surgery, antibiotic therapy.

• Characteristics of three populations will be compared :

• - OAI of urinary origin

• - OAI of another origin (skin, etc)

• - OAI without known origin Characteristics include : gender, age, risk factors, site of osteo-articular infection, type of micro-organism, type of positive sample(s), blood cultures, urinary cultures, duration of symptoms, site of primary infection and/or type of contamination, biological results, echocardiography, imaging results, type of treatment (medical, surgical), outcome, duration of hospitalization, intensive unit care stay, death at hospital. ;

Related Conditions & MeSH terms

• Articular Disease
• Bacterial Infections
• Infections
• Joint Diseases
• Urinary Tract Infections

• NCT number: NCT05007405
• Study type: Observational
• Source: Centre Hospitalier René Dubos
• Status: Completed
• Start date: February 12, 2021
• Completion date: December 31, 2021