Clinical Trials Logo
  1. Home
  2. Arthroplasty
  3. NCT00548288

Effect of Local Pamidronate in Preventing Bone Loss After Total Hip Arthroplasty

Arthroplasty Clinical Trial

Official title:
Phase 1 Study of the Effect of Local Pamidronate Application in Preventing Periprosthetic Bone Loss After Total Cemented Hip Arthroplasty

Clinical Trial Summary

The aims of the study are to determine whether pamidronate applied locally causes diminished periprosthetic bone loss and decreased rate of bone turnover compared to patients receiving placebo after cemented total hip arthroplasty (THA). The study design will be prospective, randomized, and blind. Periprosthetic bone mineral density (BMD) will be measured with dual energy X-ray absorptiometry (DXA) at the total periprosthetic area as well as at seven Gruen zones or regions of interest. DXA scans will be performed at one week (baseline), three months, and six months postoperatively. Mean values of biochemical markers of bone turnover, BMD, and baseline-normalized BMD values will be compared between the bisphosphonate and placebo groups at each time point. For all temporal measurements including bone markers, BMD and normalized BMD, mean values will be compared across each time point within a given group.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00548288
Study type Interventional
Source General and Teaching Hospital Celje
Contact Samo K Fokter, MD, PhD
Phone +38634233306
Email samo.fokter@guest.arnes.si
Status Not yet recruiting
Phase Phase 1
Start date November 2007
View Details
See also
  Status Clinical Trial Phase
Not yet recruiting NCT06323980 - INHANCE Stemless Reverse Shoulder IDE N/A
Completed NCT00762944 - Total Temporomandibular Joint Replacement System Post Approval Study
Not yet recruiting NCT05015101 - Evaluation of the Clinical and Radiological Outcome of Uncemented Femoral Stems According to Their Proximal Coating
Terminated NCT02713906 - Materialise X-ray Knee Guides for Total Knee Arthroplasty N/A
Completed NCT02554149 - Radiological Measurement of Femoral Stem Version Using Lateral Decubitus Method: A Prospective Study N/A
Recruiting NCT02828293 - Understanding GMK Sphere Implant Tibiofemoral Kinematics by Means of Dynamic Videofluoroscopy
Completed NCT02829866 - AMIStem-H Radiographic Analysis
Terminated NCT00683267 - Efficacy and Safety Study of 4975 in Patients Undergoing Total Hip Replacement Phase 2
Completed NCT04516239 - Comparison of Metal on Metal Total Hip Arthroplasty and Metal on Metal Total Hip Resurfacing. Phase 4
Recruiting NCT04480320 - Sonography-guided Pericapsular Never Group Block for Hip Arthroplasty N/A
Not yet recruiting NCT04906681 - Implementation of a Rehabilitation Technology in Orthopedic and Neurological Rehabilitation to Increase Therapy Dosage: an Exploratory Study Phase 1/Phase 2
Completed NCT04403919 - Knotless Suture in Revision Total Joint Arthroplasty N/A
Completed NCT03132831 - Influence of the Operative Day on the Average Duration of Stay in Primary Hip and Knee Replacements
Active, not recruiting NCT03339557 - Comparison of Three Knee Replacements N/A
Active, not recruiting NCT02578446 - Uncemented Tritanium Compared With Cemented Metal-backed Tibia Components in Total Knee Replacement N/A
Not yet recruiting NCT00756483 - Stability Plus - Outcomes From Extended Continuum of Care N/A
Terminated NCT00364533 - A Study to Evaluate the Effectiveness and Safety of Tapentadol(CG5503) in the Treatment of Acute Pain After Hip Replacement Surgery Compared With Oxycodone and Placebo Followed by a Voluntary Open-Label Extension For Safety Phase 3
Terminated NCT04089371 - A Post-Market Clinical Evaluation of the ReUnion Reversible Fracture (RFX) System
Completed NCT05248854 - Effects of Sensorimotor and Core Stabilization Exercises After Total Knee Arthroplasty N/A
Not yet recruiting NCT02465684 - Effect of Tourniquet on UKA N/A