Arthropathy of Knee Clinical Trial
Official title:
Diagnosis of Periprosthetic Joint Infection and the Common Pathogens, Durg-resistance in Periprosthetic Joint Infection
This retrospective study aims to improve the diagnosis of PJI as well as to identify microorganisms causing periprosthetic joint infection (PJI) and the drug-resistant spectrum
160 patients who underwent revision or re-revision total hip or knee arthroplasty for
different reasons in our institution were recruited from August 2013 to August 2016. 80
patients meet the criteria of PJI from the muscle and skeletal muscle Association (MSIS) are
divided to the infection group, another 80 patients are divided into the non-infection group.
Medical and demographic data were recorded. Collected lab examinations included blood routine
test, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), synovial leukocyte
counts, Receiver Operating Characteristic Curve-Area Under Curve (ROC-AUC) analysis will be
used to evaluate the specific and sensitivity of diagnosis index. Moreover,microorganisms
isolated from periprosthetic tissues and articular fluid. Postoperatively, the prosthesis was
sent for ultrasound sonication. The sonicate extraction, implant surrounding tissue and
synovium were sent for microbiologic culture, and the implant-surrounding-tissue were also
sent for pathological examination. The isolated strains and drug-resistance rate for each
bacterium for different antibiotics were presented.
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