Arteriovenous Malformations Clinical Trial
Official title:
Fertility After Diagnosis and Management of Acquired Uterine Arteriovenous Malformation
Uterine arteriovenous malformations (UAVM) are short circuits between systemic arterial and
venous networks within the uterus. They are congenital or acquired (in the course of an
endo-uterine gesture such as curettage or interventions such as caesareans or myomectomies).
They can be manifested by severe metrorrhagia that can go as far as to put the patient's
vital prognosis at risk.
There are no recommendations for the management of UAVM since this pathology is rare and
therefore series are performed with few cases. If some of these UAVM disappear spontaneously
after a therapeutic abstention, when the clinical context allows it, in case of symptomatic
UAVM, a selective embolization with arteriography is often carried out to postpone the
hysterectomy of hemostasis.
There are also more marginal management options such as Gonadotropin-Releasing Hormone
agonists, methotrexate or curettage that are decided on a case by case basis depending on the
symptoms and protocols of each medical team.
Regarding subsequent fertility and pregnancy outcomes after conservative treatment, the
number of studies is even lower.
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