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Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT05155514
Other study ID # Arterial stiffness
Secondary ID
Status Completed
Phase
First received
Last updated
Start date November 1, 2018
Est. completion date November 1, 2020

Study information

Verified date December 2021
Source Aydin Adnan Menderes University
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Hypertension is a disease with increasing and serious complications all over the world. In particular, the incidence of hypertension increases with advancing age. Secondary problems that can be caused by hypertension include peripheral vascular diseases, arteriosclerosis, increased risk of heart attack and stroke. It is a measurement of pulse wave velocity (PWV), a non-invasive indicator of arterial stiffness. It is known that sudden hemodynamic changes that occur during the induction of anesthesia cause undesirable intraoperative and postoperative complications. It is known that arterial stiffness, which is more common in elderly patients, causes orthostatic hypotension in particular. For this reason, more hemodynamic instability may be seen in the general anesthesia procedure in elderly patients with increased arterial stiffness. In our study, we aimed to investigate whether the hemodynamic changes observed during anesthesia induction in hypertensive elderly patients, whom we think have a high pulse wave velocity, are different from normotensive patients.


Recruitment information / eligibility

Status Completed
Enrollment 139
Est. completion date November 1, 2020
Est. primary completion date November 1, 2019
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 50 Years and older
Eligibility Inclusion Criteria: - According to the American Society of Anesthesiologists (ASA), physical condition I-II, - Elective otolaryngology surgery with endotracheal intubation planned - Patients aged 50 and over Exclusion Criteria: - Hypersensitivity to drugs - Difficult intubation history - Diabetes mellitus receiving insulin therapy - Chronic renal failure or end-stage renal disease - Heart failure (left ventricular ejection fraction =30%) - Valve disease (moderate to severe) - Atrial fibrillation

Study Design


Related Conditions & MeSH terms


Intervention

Procedure:
Mobil-O-Graph PWA
After resting in a quiet room preoperatively, blood pressure was measured on the right arm using an oscillometric method.

Locations

Country Name City State
Turkey Aydin Adnan Menderes University Faculty of Medicine, Department of Anesthesiology and Reanimation Aydin

Sponsors (1)

Lead Sponsor Collaborator
Aydin Adnan Menderes University

Country where clinical trial is conducted

Turkey, 

Outcome

Type Measure Description Time frame Safety issue
Primary Difference between hemodynamic values The difference between the hemodynamic values measured preoperatively and during anesthesia induction was calculated. In addition, =20% decrease in preoperative hemodynamic value and/or systolic blood pressure =90 mmHg hypotension, =20% increased hypertension Basal measurement before induction of anesthesia, then at 1-minute intervals until after endotracheal intubation
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