HOLT-ED: Holter-monitoring in End-stage Renal Disease

Status Active, not recruiting

Clinical Trial Summary

The main objective of this prospective cohort study is to assess arrhythmia burden and glycemic variability in a multicenter cohort of patients with end-stage renal disease using a sufficient observation period in order to identify arrhythmia burden and type and characterize associations with patient characteristics and dialysis treatment, glycemic variability and subsequent risk of adverse outcomes.

Clinical Trial Description

Background: The risk of dying of a cardiovascular disease is 10-20 times increased in patients dependent on dialysis treatment compared to the general population. 1/3 of these deaths is caused by arrhythmia and 'sudden cardiac death'. Purpose: Investigate the prevalence and type of arrhythmia in patients dependent on dialysis treatment, including the association with patient- and dialysis related factors and cardiovascular outcomes. Methods: 7-days Holter-monitoring with Cortrium C3+ holter-monitor in 540 patients dependent on dialysis treatment in the Capital Region of Denmark. Continous blood glucose monitoring in a subgroup. 1-year follow-up via national registers. Endpoints: - Prevalence of atrial fibrillation - Prevalence of other arrhythmia (tachycardia, bradycardia, AV-block) - Follow-up outcomes: sudden cardiac death, cardiovascular disease and cardiovascular death ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04876963
Study type	Observational [Patient Registry]
Source	Rigshospitalet, Denmark
Contact
Status	Active, not recruiting
Phase
Start date	September 1, 2021
Completion date	September 5, 2024

View Details

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