ARDS Clinical Trial - Nucleotide Polymorphism in ARDS Outcome

Status Completed

Clinical Trial Summary

Clinical Trial Description

Acute respiratory distress syndrome (ARDS) is characterized by increased pulmonary vascular permeability and reduced aerated lung tissue. With an extremely high hospital mortality among 35 - 46%, current therapeutic strategies to increase ARDS survival are still limited. Advances in etiology and pathology of ARDS are urging. Numerous genetic variants were identified associated with ARDS outcome. Then a few genetic risk factors have been discovered by large-scale genotyping approaches, from in vivo or in vitro models of lung injury, which highlight the importance of identifying genetic biomarkers of ARDS outcome to further improve stratification. The mutational landscape and variability at single nucleotide polymorphisms (SNP) with ARDS outcome in Chinese is unknown, not to mention their associations. By whole-exome sequencing association study, our goal was to explore the associations between genetic variants and ARDS outcome. ;

Study Design

Related Conditions & MeSH terms

ARDS

Clinical Trial Details

NCT number	NCT02644798
Study type	Observational
Source	Southeast University, China
Contact
Status	Completed
Phase
Start date	January 1, 2016
Completion date	June 30, 2017

View Details

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