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Feasabilty and Physiological Effects of a Ventilation Strategy Combining PEEP and Tidal Volume Titration According to Inspiratory and Expiratory Transpulmonary Pressures in ARDS Patients.

ARDS, Human Clinical Trial

Official title:
Feasabilty and Physiological Effects of a Ventilation Strategy Combining PEEP and Tidal Volume Titration According to Inspiratory and Expiratory Transpulmonary Pressures in ARDS Patients..

Clinical Trial Summary

Expiratory or inspiratory transpulmonary pressures have been proposed to optimize ventilator settings in patients with ARDS. The aim of this study is to assess the feasibility and the physiological effects of a new method based on both expiratory and inspiratory transpulmonary pressures.

Clinical Trial Description

Expiratory or inspiratory transpulmonary pressures have been proposed to optimize ventilator settings in patients with ARDS. A positive expiratory transpulmonary pressure may be considered as a target to limt the risk of collapse in dependant lung regions. Some authors propose to titrate PEEP to target an inspiratory transpulmonary pressure of 20cmH20 to limit the risk of overdistension in non-dependant regions.The aim of this study is to assess the feasibility and the physiological effects of a new method based on both expiratory and inspiratory transpulmonary pressures. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05337059
Study type Interventional
Source University Hospital, Angers
Contact Francois Beloncle, MD-PhD
Phone +33 2 41 35 58 65
Email francois.beloncle@univ-angers.fr
Status Recruiting
Phase N/A
Start date March 30, 2022
Completion date April 2024
View Details
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