Alveolar Macrophage Programming Following Endotoxin Exposure

Status Recruiting

Clinical Trial Summary

The histologic hallmarks of lung inflammation include accumulation of inflammatory cells in the airspaces and interstitium, injury to alveolar epithelial and endothelial cells, loss of epithelial-capillary integrity and accumulation of edema fluid in the interstitium and airspaces. Accordingly, for alveolar repair to occur inflammation must be halted, debris and inflammatory cells removed, injured tissue cells replaced, and capillary barrier function re-established. Macrophages are key players in all of these. Here the investigators hypothesize that resident alveolar macrophages and recruited macrophages serve completely different functions, acting independently (i.e. division of labor) yet cooperatively (synergism).

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

ARDS, Human
Respiratory Distress Syndrome, Adult

Clinical Trial Details

NCT number	NCT03859050
Study type	Interventional
Source	National Jewish Health
Contact	Christine Griesmer
Phone	303-398-1325
Email	griesmerc@njhealth.org
Status	Recruiting
Phase	N/A
Start date	March 18, 2019
Completion date	March 2024

View Details

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