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NCT03845556 Clinical Trial

Clinical Study of Titrating PEEP of Different Methods on Right Heart Function

ARDS, Human Clinical Trial

Official title:
Clinical Study of Titrating PEEP of Different Methods on Right Heart Function and Pulmonary Artery Pressure in ARDS Patients

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT03845556
Other study ID # ARDS
Secondary ID
Status Recruiting
Phase
First received
Last updated
Start date August 4, 2018
Est. completion date March 30, 2019

Study information
Verified date February 2019
Source Southeast University, China
Contact Dutong Yue, Dr
Phone 15051887681
Email 1475008526@qq.com
Is FDA regulated No
Health authority
Study type Observational [Patient Registry]

Clinical Trial Summary

To observe the influence of different methods titrating PEEP on right heart function and pulmonary artery pressure in ARDS patients .

Description:

30 patients who diagnosed as ARDS were included in this study.Then set PEEP with respectively ARDS net 、EIT and Esophageal Pressure in Breathing Machine . Recorded diameter of right and left ventricular TAM TAPSE pulmonary artery pressure.Objective to evaluate the correlation between the level of PEEP in three methods and the right heart function and pulmonary artery pressure in ARDS patients .

Recruitment information / eligibility
Status Recruiting
Enrollment 30
Est. completion date March 30, 2019
Est. primary completion date March 30, 2019
Accepts healthy volunteers No
Gender All
Age group 18 Years to 80 Years
Eligibility Inclusion Criteria:

- Patients admitted to ICU diagnosed of modecate to severe ARDS (Berlin criteria)

- Patients age between 18 years old and 80 years

Exclusion Criteria:

- Patients with chronic respiratory diseases such as COPD.

- Ventilated because of oesophageal surgery in the previous 12months.

- Patients who cannot obtain clear ultrasound images due to thoracic surgery ,massive pleural effusion.

- Oesophageal bleeding in previous 30 days history of oesophageal varices.

- Facial trauma and surgery.

Study Design

Related Conditions & MeSH terms

Locations
Country Name City State
China Zhongda Hospital Nanjing Jiangsu

Sponsors (2)
Lead Sponsor Collaborator
Southeast University, China Zhongda Hospital

Country where clinical trial is conducted

China, 

Outcome
Type Measure Description Time frame Safety issue
Primary the function of right heart and pulmonary artery pressure Systolic Pulmonary Artery Pressure TAPSE or Tricuspid Annular Motion orTricuspid annular plane systolic excursion or right ventricular diameter or right left ventricular diameter ratio in diffrient PEEP 2018.4-2019.3
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