Appetitive Behavior Clinical Trial
Official title:
Effects of Acute Cannabidiol (CBD) Supplementation on Nutrient Metabolism and Energy Intake in Healthy Adults
Verified date | August 2023 |
Source | Loughborough University |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
CBD may affect metabolic control and energy intake. However, there is currently little data regarding these specific outcomes in humans. Therefore, this study will investigate whether a single 300 mg dose of CBD can improve metabolic control following a meal and/or reduce energy intake at a subsequent meal. Healthy, adult volunteers will complete two conditions in a crossover design, comparing outcomes following both CBD and placebo supplementation.
Status | Active, not recruiting |
Enrollment | 15 |
Est. completion date | August 31, 2023 |
Est. primary completion date | March 30, 2022 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 50 Years |
Eligibility | Inclusion Criteria: • Self-report as healthy, male or female, aged 18-50, body mass index =18.5 and <30.0 Exclusion Criteria: - Currently engage in >10 hours moderate or vigorous intensity physical activity per week - Have consumed CBD or cannabis at all within the past two months - Have used CBD or cannabis regularly (>2x in a week) within the past four months - Are suffering from any clinically significant illness - Have regularly used tobacco within the previous 6 months (> 2/week) - Currently use any prescription or over-the-counter medications (except for hormonal contraception and simple painkillers) - Have given a standard blood donation within 30 days of screening - Are currently pregnant or lactating - Are allergic/intolerant to any ingredients in food items provided during the study |
Country | Name | City | State |
---|---|---|---|
United Kingdom | Loughborough University | Loughborough | Leicestershire |
Lead Sponsor | Collaborator |
---|---|
Loughborough University |
United Kingdom,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Energy intake | Self-selected energy intake at an ad libitum mixed meal | ~5-30 minutes (time taken to eat a single meal) | |
Primary | Postprandial Glycaemia | Plasma glucose response to a mixed meal (plasma glucose concentrations and area under curve) | 3 hours | |
Primary | Postprandial Triglyceridaemia | Plasma triglyceride response to a mixed meal (plasma triglyceride concentrations and area under curve) | 3 hours | |
Secondary | Postprandial Insulinaemia | Plasma Insulin response to a mixed meal (plasma insulin concentrations and area under curve) | 3 hours |
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