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NCT05572385 Clinical Trial

Clinic and Neurophysiology of Aphasia Treatment

Aphasia, Acquired Clinical Trial

— AphasRehab  

Official title:
Clinical and Neurophysiological Features of Neurorehabilitation Effects in Cerebrovascular Aphasia

Clinical Trial Details — Status: Not yet recruiting

Administrative data
NCT number NCT05572385
Other study ID # EK-BR-157/20-1
Secondary ID
Status Not yet recruiting
Phase N/A
First received
Last updated
Start date July 1, 2023
Est. completion date December 31, 2026

Study information
Verified date October 2022
Source Klinik Bavaria
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

In the planned study, clinical and electrophysiological features of aphasia recovery in stroke patients are investigated.

Description:

Clinical neurorehabilitation faces a major challenge of functional recovery in aphasia, i.e. guiding the structural and temporal dynamics of reorganization within responsible neural networks. Here, according to current research, relevant neural factors affecting the treatment and thus the functional recovery of aphasia patients after stroke are of interest, highlighting structural as well as functional neuroanatomical features. Of particular interest are not only the functional localization of affected cerebral regions, but more the clinical and neurophysiological patterns which might help to factorize and predict the therapeutic outcome. In the planned study, the clinical and neurophysiological characteristics of the dynamics of language function recovery in relation to the intensity of professional speech therapy (constraint induced aphasia therapie - CIAT) will be recorded in 40 patients with aphasia resulting from a cerebrovascular event. The aim of this study is to test the value of neurophysiological aspects based on electroencephalographic (EEG) parameters such as event-related potentials (N400, P600, theta band activity) for the identification of specific neuronal markers, which in turn support predictive statements for individual therapy planning of logopedic treatment in neurorehabilitation.

Recruitment information / eligibility
Status Not yet recruiting
Enrollment 40
Est. completion date December 31, 2026
Est. primary completion date December 31, 2025
Accepts healthy volunteers No
Gender All
Age group N/A and older
Eligibility Inclusion Criteria: - patients with a cerebrovascular event Exclusion Criteria: - premorbid brain disorder

Study Design

Related Conditions & MeSH terms

Intervention

Behavioral:
• CIAT + Conventional neurorehabilitative therapy
CIAT = Constrained induced aphasia therapy

Locations
Country Name City State
n/a

Sponsors (1)
Lead Sponsor Collaborator
Klinik Bavaria

Outcome
Type Measure Description Time frame Safety issue
Primary EEG correlates of language reconstitution Identitification of EEG features (N400, P600, Theta band activity) that correlate with clinical outcome of language reconstitution. 3-6 months after stroke
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