Parkinson Disease Clinical Trial
Official title:
Non Motors Aspects in De Novo Parkinson's Disease: Clinical and Physiopathological Description; Dopamine Agonist Treatment Effects.
Clinical description and pathophysiological study of recently diagnosed untreated patients
with Parkinson's Disease.
Effect of a dopamine agonist (rotigotine) on apathy in de novo patients with Parkinson
disease: A controlled, randomized, double blind study.
This study aims to show the impact of a treatment with a D2/D3 receptor-specific dopamine
agonist on the hypo-dopaminergic syndrome and quality of life of patients with de-novo
Parkinson's disease.
The study consists of three parts:
1. The first part consists of a detailed clinical description of these patients, focusing
on neuropsychological symptoms. The objective is to describe patients with and without
apathy and hypo-dopaminergic syndrome.
2. From this population, a small number of patients with and without hypo-dopaminergic
syndrome will be selected in order to compare serotoninergic and dopaminergic
denervation by positron emission tomography (PET).
3. In patients with hypo-dopaminergic syndrome the motivational effects of a dopamine
agonist will be tested in a randomized, double-blind, placebo-controlled study.
We hypothesize a significant improvement of apathy in the rotigotine group versus placebo
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