Aortic Valve Stenosis Clinical Trial
Official title:
What Are the Changes in Cardiac Deformation Variables and Hemodynamic Parameters Following Changes in Cardiac Loading Conditions and After Administration of Two Different Inotropic Drugs.
Verified date | May 2017 |
Source | Sahlgrenska University Hospital, Sweden |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
The investigators want to compare the effects of two drugs, levosimendan and milrinone, on
cardiac muscle, both in terms of contractility and relaxation. Half of the participants will
be randomized to each drug. The effects will be measured through echocardiographic
deformation analyses.
Since deformation analyses could be dependent on different loading conditions of the heart,
a second purpose of the study is to investigate the changes on deformation parameters after
applied changes in preload and afterload, but also heart rate.
Status | Completed |
Enrollment | 30 |
Est. completion date | May 2017 |
Est. primary completion date | May 2016 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: - Subject has aortic valve stenosis - Subject is scheduled for open heart aortic valve replacement with or without simultaneous coronary artery bypass grafting Exclusion Criteria: - Less than normal systolic function, defined as ejection fraction less than 0,5 - Non-sinus rhythm - Any major surgical complication - Problems understanding the informed consent |
Country | Name | City | State |
---|---|---|---|
Sweden | Thoraxoperation/TIVA, Sahlgrenska universitetssjukhuset | Göteborg |
Lead Sponsor | Collaborator |
---|---|
Sahlgrenska University Hospital, Sweden |
Sweden,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Change in diastolic strain rate | Diastolic strain rate defined as peak E wave strain rate as measured by 2D speckle tracking of the left ventricular wall. | After each physiologic intervention, and at 30 and 60 min after start of iv infusion of drug. | |
Secondary | Change in systolic strain and strain rate | Systolic strain and strain rate defined as their respective peak values during systole, measured by 2D speckle tracking of the left ventricular wall. | After each physiologic intervention, and at 30 and 60 min after start of iv infusion of drug. | |
Secondary | Change in cardiac output | Measured through pulmonary artery thermodilution as liters per minute. A baseline measurement is done before infusion is started. | After each physiologic intervention, and at 30 and 60 min after start of iv infusion of drug. |
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