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The Scottish Aortic Stenosis LongiTudinal Imaging and biomarkeR (SALTIRE) Programme — SALTIRE  

Aortic Stenosis Clinical Trial

Official title:
The Scottish Aortic Stenosis LongiTudinal Imaging and biomarkeR (SALTIRE) Programme

Clinical Trial Summary

The goal of this observational study is to understand the processes of what causes and accelerates the disease progress in aortic stenosis and following aortic valve replacement. Participants will undergo transthoracic echocardiography every 6 months, with annual visits for state-of-the-art scanning techniques including positron-emission tomography combined with computed tomography or magnetic resonance imaging with radiotracers designed to look at disease processes including fibrosis, calcification, inflammation and thrombosis activity.

Clinical Trial Description

This will be an observational cohort study using existing and prospectively recruited cohorts for both cross-sectional and longitudinal comparison across the spectrum of aortic stenosis severity. For existing cohorts of patients who have previously undergone research assessments, we will invite them for repeated assessments. Participants will be reviewed every 6 months in the Clinical Research Facility (CRF) over a 4-year period. They will undergo clinical assessment, blood sampling, transthoracic echocardiography and advanced imaging annually including CT angiography, magnetic resonance and positron emission tomography (PET). ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06047561
Study type Observational
Source University of Edinburgh
Contact Neil Craig
Phone 07383558066
Email neil.craig@ed.ac.uk
Status Recruiting
Phase
Start date May 22, 2023
Completion date May 22, 2028
View Details
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